Identification, using sera from exposed animals, of putative viral antigens in livers of primates with callitrichid hepatitis

Charles B. Stephensen, Richard J. Montali, Edward C. Ramsay, Kathryn V. Holmes

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Callitrichid hepatitis (CH) is an acute, frequently fatal viral hepatitis which affects members of the primate family Callitrichidae (R. J. Montali, E. C. Ramsay, C. B. Stephensen, M. Worley, J. A. Davis, and K. V. Holmes, J. Infect. Dis. 160:759-765, 1989; E. C. Ramsay, R. J. Montali, M. Worley, C. B. Stephensen, and K. V. Hlmes, J. Zoo Wildlife Med. 20:178-183). Outbreaks of the disease occur in zoos and animal parks. In this study, CH-specific antigens were identified in the livers of infected animals by iusing immune sera from primates with CH and CH-exposed asymptomatic animals. Three CH-specific antigens with apparent molecular masses of 34, 54, and 65 kDa were identified. A polyclonal antiserum was raised against the 54-kDa antigen. these antigens were not found in the livers of uninfected animals and may be viral proteins. Our results suggest that at least five of the six outbreaks of CH considered here were caused by the same virus or by an antigenically related virus.

Original languageEnglish (US)
Pages (from-to)6349-6354
Number of pages6
JournalJournal of Virology
Volume64
Issue number12
StatePublished - 1990
Externally publishedYes

ASJC Scopus subject areas

  • Immunology

Fingerprint Dive into the research topics of 'Identification, using sera from exposed animals, of putative viral antigens in livers of primates with callitrichid hepatitis'. Together they form a unique fingerprint.

Cite this