Identification of ubiquitin ligases required for skeletal Muscle Atrophy

S. C. Bodine, E. Latres, S. Baumhueter, V. K M Lai, L. Nunez, B. A. Clarke, W. T. Poueymirou, F. J. Panaro, Na Erqian Na, K. Dharmarajan, Z. Q. Pan, D. M. Valenzuela, T. M. Dechiara, T. N. Stitt, G. D. Yancopoulos, D. J. Glass

Research output: Contribution to journalArticle

2070 Citations (Scopus)

Abstract

Skeletal muscle adapts to decreases in activity and load by undergoing atrophy. To identify candidate molecular mediators of muscle atrophy, we performed transcript profiling. Although many genes were up-regulated in a single rat model of atrophy, only a small subset was universal in all atrophy models. Two of these genes encode ubiquitin ligases: Muscle RING Finger 1 (MuRF1), and a gene we designate Muscle Atrophy F-box (MAFbx), the latter being a member of the SCF family of E3 ubiquitin ligases. Overexpression of MAFbx in myotubes produced atrophy, whereas mice deficient in either MAFbx or MuRF1 were found to be resistant to atrophy. These proteins are potentail drug targets for the treatment of muscle atrophy.

Original languageEnglish (US)
Pages (from-to)1704-1708
Number of pages5
JournalScience
Volume294
Issue number5547
DOIs
StatePublished - Nov 23 2001
Externally publishedYes

Fingerprint

Muscular Atrophy
Ligases
Ubiquitin
Atrophy
Skeletal Muscle
Genes
Muscles
Ubiquitin-Protein Ligases
Skeletal Muscle Fibers
Pharmaceutical Preparations
Proteins

ASJC Scopus subject areas

  • General

Cite this

Bodine, S. C., Latres, E., Baumhueter, S., Lai, V. K. M., Nunez, L., Clarke, B. A., ... Glass, D. J. (2001). Identification of ubiquitin ligases required for skeletal Muscle Atrophy. Science, 294(5547), 1704-1708. https://doi.org/10.1126/science.1065874

Identification of ubiquitin ligases required for skeletal Muscle Atrophy. / Bodine, S. C.; Latres, E.; Baumhueter, S.; Lai, V. K M; Nunez, L.; Clarke, B. A.; Poueymirou, W. T.; Panaro, F. J.; Erqian Na, Na; Dharmarajan, K.; Pan, Z. Q.; Valenzuela, D. M.; Dechiara, T. M.; Stitt, T. N.; Yancopoulos, G. D.; Glass, D. J.

In: Science, Vol. 294, No. 5547, 23.11.2001, p. 1704-1708.

Research output: Contribution to journalArticle

Bodine, SC, Latres, E, Baumhueter, S, Lai, VKM, Nunez, L, Clarke, BA, Poueymirou, WT, Panaro, FJ, Erqian Na, N, Dharmarajan, K, Pan, ZQ, Valenzuela, DM, Dechiara, TM, Stitt, TN, Yancopoulos, GD & Glass, DJ 2001, 'Identification of ubiquitin ligases required for skeletal Muscle Atrophy', Science, vol. 294, no. 5547, pp. 1704-1708. https://doi.org/10.1126/science.1065874
Bodine SC, Latres E, Baumhueter S, Lai VKM, Nunez L, Clarke BA et al. Identification of ubiquitin ligases required for skeletal Muscle Atrophy. Science. 2001 Nov 23;294(5547):1704-1708. https://doi.org/10.1126/science.1065874
Bodine, S. C. ; Latres, E. ; Baumhueter, S. ; Lai, V. K M ; Nunez, L. ; Clarke, B. A. ; Poueymirou, W. T. ; Panaro, F. J. ; Erqian Na, Na ; Dharmarajan, K. ; Pan, Z. Q. ; Valenzuela, D. M. ; Dechiara, T. M. ; Stitt, T. N. ; Yancopoulos, G. D. ; Glass, D. J. / Identification of ubiquitin ligases required for skeletal Muscle Atrophy. In: Science. 2001 ; Vol. 294, No. 5547. pp. 1704-1708.
@article{e8838415c05a41caa02f2fa5600bff62,
title = "Identification of ubiquitin ligases required for skeletal Muscle Atrophy",
abstract = "Skeletal muscle adapts to decreases in activity and load by undergoing atrophy. To identify candidate molecular mediators of muscle atrophy, we performed transcript profiling. Although many genes were up-regulated in a single rat model of atrophy, only a small subset was universal in all atrophy models. Two of these genes encode ubiquitin ligases: Muscle RING Finger 1 (MuRF1), and a gene we designate Muscle Atrophy F-box (MAFbx), the latter being a member of the SCF family of E3 ubiquitin ligases. Overexpression of MAFbx in myotubes produced atrophy, whereas mice deficient in either MAFbx or MuRF1 were found to be resistant to atrophy. These proteins are potentail drug targets for the treatment of muscle atrophy.",
author = "Bodine, {S. C.} and E. Latres and S. Baumhueter and Lai, {V. K M} and L. Nunez and Clarke, {B. A.} and Poueymirou, {W. T.} and Panaro, {F. J.} and {Erqian Na}, Na and K. Dharmarajan and Pan, {Z. Q.} and Valenzuela, {D. M.} and Dechiara, {T. M.} and Stitt, {T. N.} and Yancopoulos, {G. D.} and Glass, {D. J.}",
year = "2001",
month = "11",
day = "23",
doi = "10.1126/science.1065874",
language = "English (US)",
volume = "294",
pages = "1704--1708",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "5547",

}

TY - JOUR

T1 - Identification of ubiquitin ligases required for skeletal Muscle Atrophy

AU - Bodine, S. C.

AU - Latres, E.

AU - Baumhueter, S.

AU - Lai, V. K M

AU - Nunez, L.

AU - Clarke, B. A.

AU - Poueymirou, W. T.

AU - Panaro, F. J.

AU - Erqian Na, Na

AU - Dharmarajan, K.

AU - Pan, Z. Q.

AU - Valenzuela, D. M.

AU - Dechiara, T. M.

AU - Stitt, T. N.

AU - Yancopoulos, G. D.

AU - Glass, D. J.

PY - 2001/11/23

Y1 - 2001/11/23

N2 - Skeletal muscle adapts to decreases in activity and load by undergoing atrophy. To identify candidate molecular mediators of muscle atrophy, we performed transcript profiling. Although many genes were up-regulated in a single rat model of atrophy, only a small subset was universal in all atrophy models. Two of these genes encode ubiquitin ligases: Muscle RING Finger 1 (MuRF1), and a gene we designate Muscle Atrophy F-box (MAFbx), the latter being a member of the SCF family of E3 ubiquitin ligases. Overexpression of MAFbx in myotubes produced atrophy, whereas mice deficient in either MAFbx or MuRF1 were found to be resistant to atrophy. These proteins are potentail drug targets for the treatment of muscle atrophy.

AB - Skeletal muscle adapts to decreases in activity and load by undergoing atrophy. To identify candidate molecular mediators of muscle atrophy, we performed transcript profiling. Although many genes were up-regulated in a single rat model of atrophy, only a small subset was universal in all atrophy models. Two of these genes encode ubiquitin ligases: Muscle RING Finger 1 (MuRF1), and a gene we designate Muscle Atrophy F-box (MAFbx), the latter being a member of the SCF family of E3 ubiquitin ligases. Overexpression of MAFbx in myotubes produced atrophy, whereas mice deficient in either MAFbx or MuRF1 were found to be resistant to atrophy. These proteins are potentail drug targets for the treatment of muscle atrophy.

UR - http://www.scopus.com/inward/record.url?scp=0035941020&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035941020&partnerID=8YFLogxK

U2 - 10.1126/science.1065874

DO - 10.1126/science.1065874

M3 - Article

VL - 294

SP - 1704

EP - 1708

JO - Science

JF - Science

SN - 0036-8075

IS - 5547

ER -