Identification of ubiquitin ligases required for skeletal Muscle Atrophy

S. C. Bodine, E. Latres, S. Baumhueter, V. K M Lai, L. Nunez, B. A. Clarke, W. T. Poueymirou, F. J. Panaro, Na Erqian Na, K. Dharmarajan, Z. Q. Pan, D. M. Valenzuela, T. M. Dechiara, T. N. Stitt, G. D. Yancopoulos, D. J. Glass

Research output: Contribution to journalArticle

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Abstract

Skeletal muscle adapts to decreases in activity and load by undergoing atrophy. To identify candidate molecular mediators of muscle atrophy, we performed transcript profiling. Although many genes were up-regulated in a single rat model of atrophy, only a small subset was universal in all atrophy models. Two of these genes encode ubiquitin ligases: Muscle RING Finger 1 (MuRF1), and a gene we designate Muscle Atrophy F-box (MAFbx), the latter being a member of the SCF family of E3 ubiquitin ligases. Overexpression of MAFbx in myotubes produced atrophy, whereas mice deficient in either MAFbx or MuRF1 were found to be resistant to atrophy. These proteins are potentail drug targets for the treatment of muscle atrophy.

Original languageEnglish (US)
Pages (from-to)1704-1708
Number of pages5
JournalScience
Volume294
Issue number5547
DOIs
StatePublished - Nov 23 2001
Externally publishedYes

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    Bodine, S. C., Latres, E., Baumhueter, S., Lai, V. K. M., Nunez, L., Clarke, B. A., Poueymirou, W. T., Panaro, F. J., Erqian Na, N., Dharmarajan, K., Pan, Z. Q., Valenzuela, D. M., Dechiara, T. M., Stitt, T. N., Yancopoulos, G. D., & Glass, D. J. (2001). Identification of ubiquitin ligases required for skeletal Muscle Atrophy. Science, 294(5547), 1704-1708. https://doi.org/10.1126/science.1065874