Identification of TRACs (T3 receptor-associating cofactors), a family of cofactors that associate with, and modulate the activity of, nuclear hormone receptors

Stephen Sande, Martin L. Privalsky

Research output: Contribution to journalArticle

200 Citations (Scopus)

Abstract

Nuclear hormone receptors are the largest known family of eukaryotic transcription factors and serve as critical effectors of vertebrate homeostasis, growth, and differentiation. The precise transcriptional response mediated by a given nuclear hormone receptor is dictated by hormone, promoter, and cellular context, and many nuclear hormone receptors function bimodally as both transcriptional activators and repressors. We report here the identification of a family of proteins, denoted TRACs (T3 receptor- associating cofactors), which physically interact with nuclear hormone receptors and can modulate the transcriptional properties of these receptors. TRACs associate with retinoic acid, retinoid X, and thyroid hormone receptors, as well as the PML-RARα and v-Erb A oncoproteins. Certain TRAC forms attenuate target gene expression and may serve as corepressors, whereas other TRAC family members appear to counteract these effects. We suggest that TRACs and related cofactors may participate in dictating the pleiotropic transcriptional capacities of the nuclear hormone receptors.

Original languageEnglish (US)
Pages (from-to)813-825
Number of pages13
JournalMolecular Endocrinology
Volume10
Issue number7
DOIs
StatePublished - 1996

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Thyroid Hormone Receptors
Cytoplasmic and Nuclear Receptors
Co-Repressor Proteins
Oncogene Proteins
Retinoids
Tretinoin
Vertebrates
Homeostasis
Transcription Factors
Hormones
Gene Expression
Growth
Proteins

ASJC Scopus subject areas

  • Molecular Biology
  • Endocrinology, Diabetes and Metabolism

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Identification of TRACs (T3 receptor-associating cofactors), a family of cofactors that associate with, and modulate the activity of, nuclear hormone receptors. / Sande, Stephen; Privalsky, Martin L.

In: Molecular Endocrinology, Vol. 10, No. 7, 1996, p. 813-825.

Research output: Contribution to journalArticle

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