Identification of the UV-responsive sequence in the human tissue plasminogen activator gene

Jun Fujiwara; Michihiko Fujii; Michiko Shimoda; Dai Ayusawa

doi:10.1271/bbb.64.1084

Identification of the UV-responsive sequence in the human tissue plasminogen activator gene

Jun Fujiwara, Michihiko Fujii, Michiko Shimoda, Dai Ayusawa

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Functional analysis of regulatory elements in the human tissue plasminogen activator (tPA) gene showed that its promoter (-119/+169) is activated by UV irradiation in HeLa cells. We demonstrated here that the AP-2 like CCCCACCC sequence is involved in the UV-mediated activation and Sp1 binds to the sequence.

Original language	English (US)
Pages (from-to)	1084-1087
Number of pages	4
Journal	Bioscience, Biotechnology and Biochemistry
Volume	64
Issue number	5
DOIs	https://doi.org/10.1271/bbb.64.1084
State	Published - Jan 1 2000
Externally published	Yes

Keywords

AP-2-like
CAT assay
Spl
Tissue plasminogen activator
UV

ASJC Scopus subject areas

Biotechnology
Analytical Chemistry
Biochemistry
Applied Microbiology and Biotechnology
Molecular Biology
Organic Chemistry

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AU - Shimoda, Michiko

AU - Ayusawa, Dai

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AB - Functional analysis of regulatory elements in the human tissue plasminogen activator (tPA) gene showed that its promoter (-119/+169) is activated by UV irradiation in HeLa cells. We demonstrated here that the AP-2 like CCCCACCC sequence is involved in the UV-mediated activation and Sp1 binds to the sequence.

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KW - UV

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Identification of the UV-responsive sequence in the human tissue plasminogen activator gene

Abstract

Keywords

ASJC Scopus subject areas

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