Abstract
Functional analysis of regulatory elements in the human tissue plasminogen activator (tPA) gene showed that its promoter (-119/+169) is activated by UV irradiation in HeLa cells. We demonstrated here that the AP-2 like CCCCACCC sequence is involved in the UV-mediated activation and Sp1 binds to the sequence.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1084-1087 |
| Number of pages | 4 |
| Journal | Bioscience, Biotechnology and Biochemistry |
| Volume | 64 |
| Issue number | 5 |
| DOIs | |
| State | Published - Jan 1 2000 |
| Externally published | Yes |
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Keywords
- AP-2-like
- CAT assay
- Spl
- Tissue plasminogen activator
- UV
ASJC Scopus subject areas
- Biotechnology
- Analytical Chemistry
- Biochemistry
- Applied Microbiology and Biotechnology
- Molecular Biology
- Organic Chemistry
Cite this
Identification of the UV-responsive sequence in the human tissue plasminogen activator gene. / Fujiwara, Jun; Fujii, Michihiko; Shimoda, Michiko; Ayusawa, Dai.
In: Bioscience, Biotechnology and Biochemistry, Vol. 64, No. 5, 01.01.2000, p. 1084-1087.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Identification of the UV-responsive sequence in the human tissue plasminogen activator gene
AU - Fujiwara, Jun
AU - Fujii, Michihiko
AU - Shimoda, Michiko
AU - Ayusawa, Dai
PY - 2000/1/1
Y1 - 2000/1/1
N2 - Functional analysis of regulatory elements in the human tissue plasminogen activator (tPA) gene showed that its promoter (-119/+169) is activated by UV irradiation in HeLa cells. We demonstrated here that the AP-2 like CCCCACCC sequence is involved in the UV-mediated activation and Sp1 binds to the sequence.
AB - Functional analysis of regulatory elements in the human tissue plasminogen activator (tPA) gene showed that its promoter (-119/+169) is activated by UV irradiation in HeLa cells. We demonstrated here that the AP-2 like CCCCACCC sequence is involved in the UV-mediated activation and Sp1 binds to the sequence.
KW - AP-2-like
KW - CAT assay
KW - Spl
KW - Tissue plasminogen activator
KW - UV
UR - http://www.scopus.com/inward/record.url?scp=0034183822&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034183822&partnerID=8YFLogxK
U2 - 10.1271/bbb.64.1084
DO - 10.1271/bbb.64.1084
M3 - Article
C2 - 10879489
AN - SCOPUS:0034183822
VL - 64
SP - 1084
EP - 1087
JO - Bioscience, biotechnology, and biochemistry
JF - Bioscience, biotechnology, and biochemistry
SN - 0916-8451
IS - 5
ER -