Identification of the UV-responsive sequence in the human tissue plasminogen activator gene

Jun Fujiwara, Michihiko Fujii, Michiko Shimoda, Dai Ayusawa

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Functional analysis of regulatory elements in the human tissue plasminogen activator (tPA) gene showed that its promoter (-119/+169) is activated by UV irradiation in HeLa cells. We demonstrated here that the AP-2 like CCCCACCC sequence is involved in the UV-mediated activation and Sp1 binds to the sequence.

Original languageEnglish (US)
Pages (from-to)1084-1087
Number of pages4
JournalBioscience, Biotechnology and Biochemistry
Volume64
Issue number5
DOIs
StatePublished - Jan 1 2000
Externally publishedYes

Keywords

  • AP-2-like
  • CAT assay
  • Spl
  • Tissue plasminogen activator
  • UV

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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