Abstract
Functional analysis of regulatory elements in the human tissue plasminogen activator (tPA) gene showed that its promoter (-119/+169) is activated by UV irradiation in HeLa cells. We demonstrated here that the AP-2 like CCCCACCC sequence is involved in the UV-mediated activation and Sp1 binds to the sequence.
Original language | English (US) |
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Pages (from-to) | 1084-1087 |
Number of pages | 4 |
Journal | Bioscience, Biotechnology and Biochemistry |
Volume | 64 |
Issue number | 5 |
DOIs | |
State | Published - Jan 1 2000 |
Externally published | Yes |
Keywords
- AP-2-like
- CAT assay
- Spl
- Tissue plasminogen activator
- UV
ASJC Scopus subject areas
- Biotechnology
- Analytical Chemistry
- Biochemistry
- Applied Microbiology and Biotechnology
- Molecular Biology
- Organic Chemistry