Identification of the Marek's Disease Virus Serotype 2 Genes Homologous to the Glycoprotein B (UL27), ICP18.5 (UL28) and Major DNA-Binding Protein (UL29) Genes of Herpes Simplex Virus Type 1

Kentaro Kato, Hyung Kwan Jang, Yoshihiro Izumiya, Jin Shun Cai, Yoshinori Tsushima, Takayuki Miyazawa, Chieko Kai, Takeshi Mikami

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

We determined the nucleotide sequence of non-pathogenic Marek's disease virus serotype 2 (MDV2) strain HPRS24 glycoprotein B (gB) (UL27), ICP18.5 (UL28) and major DNA-binding protein (MDBP) (UL29) genes homologous to herpes simplex virus type 1 (HSV-1). The sequence data revealed that important motives in the proteins are conserved in MDV2 ICP 18.5 and MDBP, however the sequence of viral DNA replication origin which exists in the regions between the UL29 and UL30 genes of other alphaherpesviruses was not found in the regions of the MDV2 genome. By northern blot analyses, we also demonstrated that 8.9, 5.0 and 2.6 kb transcripts were actually transcribed from the sequenced region in MDV2-infected cells. The MDV2 UL28 and UL29 genes have not been reported in other scrotypes of MDV.

Original languageEnglish (US)
Pages (from-to)1161-1165
Number of pages5
JournalJournal of Veterinary Medical Science
Volume61
Issue number10
StatePublished - Oct 1999
Externally publishedYes

Fingerprint

Gallid Herpesvirus 3
Human herpesvirus 1
Mardivirus
DNA-binding proteins
DNA-Binding Proteins
Human Herpesvirus 1
glycoproteins
Glycoproteins
serotypes
Genes
genes
replication origin
Replication Origin
Viral DNA
DNA replication
DNA Replication
Northern blotting
Northern Blotting
amino acid sequences
Glycoprotein

Keywords

  • Marek's disease virus serotype 2
  • Transcript
  • UL27-UL29

ASJC Scopus subject areas

  • veterinary(all)
  • Marketing

Cite this

Identification of the Marek's Disease Virus Serotype 2 Genes Homologous to the Glycoprotein B (UL27), ICP18.5 (UL28) and Major DNA-Binding Protein (UL29) Genes of Herpes Simplex Virus Type 1. / Kato, Kentaro; Jang, Hyung Kwan; Izumiya, Yoshihiro; Cai, Jin Shun; Tsushima, Yoshinori; Miyazawa, Takayuki; Kai, Chieko; Mikami, Takeshi.

In: Journal of Veterinary Medical Science, Vol. 61, No. 10, 10.1999, p. 1161-1165.

Research output: Contribution to journalArticle

Kato, Kentaro ; Jang, Hyung Kwan ; Izumiya, Yoshihiro ; Cai, Jin Shun ; Tsushima, Yoshinori ; Miyazawa, Takayuki ; Kai, Chieko ; Mikami, Takeshi. / Identification of the Marek's Disease Virus Serotype 2 Genes Homologous to the Glycoprotein B (UL27), ICP18.5 (UL28) and Major DNA-Binding Protein (UL29) Genes of Herpes Simplex Virus Type 1. In: Journal of Veterinary Medical Science. 1999 ; Vol. 61, No. 10. pp. 1161-1165.
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