TY - JOUR
T1 - Identification of deletion mutations and three new genes at the familial polyposis locus
AU - Joslyn, Geoff
AU - Carlson, Mary
AU - Thliveris, Andrew
AU - Albertsen, Hans
AU - Gelbert, Lawrence
AU - Samowitz, Wade
AU - Groden, Joanna
AU - Stevens, Jeff
AU - Spirio, Lisa
AU - Robertson, Margaret
AU - Sargeant, Leslie
AU - Krapcho, Karen
AU - Wolff, Erika
AU - Burt, Randall
AU - Hughes, J. P.
AU - Warrington, Janet
AU - Mcpherson, John Douglas
AU - Wasmuth, John
AU - Le Paslier, Denis
AU - Abderrahim, Hadi
AU - Cohen, Daniel
AU - Leppert, Mark
AU - White, Ray
PY - 1991/8/9
Y1 - 1991/8/9
N2 - Small (100-260 kb), nested deletions were characterized in DNA from two unrelated patients with familial adenomatous polyposis coli (APC). Three candidate genes located within the deleted region were ascertained and a previous candidate gene, MCC, was shown to be located outside the deleted region. One of the new genes contained sequence identical to SRP19, the gene coding for the 19 kd component of the ribosomal signal recognition particle. The second, provisionally designated DP1 (deleted in polyposis 1), was found to be transcribed in the same orientation as MCC. Two other cDNAs, DP2 and DP3, were found to overlap, forming a single gene, DP2.5, that is transcribed in the same orientation as SRP19.
AB - Small (100-260 kb), nested deletions were characterized in DNA from two unrelated patients with familial adenomatous polyposis coli (APC). Three candidate genes located within the deleted region were ascertained and a previous candidate gene, MCC, was shown to be located outside the deleted region. One of the new genes contained sequence identical to SRP19, the gene coding for the 19 kd component of the ribosomal signal recognition particle. The second, provisionally designated DP1 (deleted in polyposis 1), was found to be transcribed in the same orientation as MCC. Two other cDNAs, DP2 and DP3, were found to overlap, forming a single gene, DP2.5, that is transcribed in the same orientation as SRP19.
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U2 - 10.1016/0092-8674(81)90022-2
DO - 10.1016/0092-8674(81)90022-2
M3 - Article
C2 - 1678319
AN - SCOPUS:0025941471
VL - 66
SP - 601
EP - 613
JO - Cell
JF - Cell
SN - 0092-8674
IS - 3
ER -