Identification of agrinSN isoform and muscle-specific receptor tyrosine kinase in sperm

Priyadarsini Kumar; Michael J Ferns; Stanley Meizel

doi:10.1016/j.bbrc.2006.01.161

Identification of agrin_SN isoform and muscle-specific receptor tyrosine kinase in sperm

Priyadarsini Kumar, Michael J Ferns, Stanley Meizel

Anesthesiology and Pain Medicine

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

We previously demonstrated several nicotinic acetylcholine receptor (nAChR) subunits and associated proteins in human sperm. Here, we identified in sperm for the first time two additional nAChR-associated molecules: (1) agrin _SNZ⁺ in human sperm localized in the posterior post-acrosomal, neck, and flagellar mid-piece regions; (2) a low-molecular weight isoform of muscle-specific receptor tyrosine kinase in human and mouse sperm localized in the flagellar mid-piece of human sperm.

Original language	English (US)
Pages (from-to)	522-528
Number of pages	7
Journal	Biochemical and Biophysical Research Communications
Volume	342
Issue number	2
DOIs	https://doi.org/10.1016/j.bbrc.2006.01.161
State	Published - Apr 7 2006

Keywords

Agrin
Muscle-specific receptor tyrosine kinase
nAChR
Sperm

ASJC Scopus subject areas

Biochemistry
Biophysics
Molecular Biology

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10.1016/j.bbrc.2006.01.161

Cite this

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abstract = "We previously demonstrated several nicotinic acetylcholine receptor (nAChR) subunits and associated proteins in human sperm. Here, we identified in sperm for the first time two additional nAChR-associated molecules: (1) agrin SNZ+ in human sperm localized in the posterior post-acrosomal, neck, and flagellar mid-piece regions; (2) a low-molecular weight isoform of muscle-specific receptor tyrosine kinase in human and mouse sperm localized in the flagellar mid-piece of human sperm.",

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AU - Kumar, Priyadarsini

AU - Ferns, Michael J

AU - Meizel, Stanley

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N2 - We previously demonstrated several nicotinic acetylcholine receptor (nAChR) subunits and associated proteins in human sperm. Here, we identified in sperm for the first time two additional nAChR-associated molecules: (1) agrin SNZ+ in human sperm localized in the posterior post-acrosomal, neck, and flagellar mid-piece regions; (2) a low-molecular weight isoform of muscle-specific receptor tyrosine kinase in human and mouse sperm localized in the flagellar mid-piece of human sperm.

AB - We previously demonstrated several nicotinic acetylcholine receptor (nAChR) subunits and associated proteins in human sperm. Here, we identified in sperm for the first time two additional nAChR-associated molecules: (1) agrin SNZ+ in human sperm localized in the posterior post-acrosomal, neck, and flagellar mid-piece regions; (2) a low-molecular weight isoform of muscle-specific receptor tyrosine kinase in human and mouse sperm localized in the flagellar mid-piece of human sperm.

KW - Agrin

KW - Muscle-specific receptor tyrosine kinase

KW - nAChR

KW - Sperm

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