Identification of a key structural feature of cobalt(III)-bleomycins: An exogenous ligand (e.g. Hydroperoxide) bound to cobalt

By Chien Hsing Chang, Jerry L. Dallas, Claude F. Meares

Research output: Contribution to journalArticle

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Abstract

A series of cobalt(III) complexes of the anticancer antibiotic bleomycin has been prepared. Mass spectrometry and enzymatic analysis show that the green cobalt-bleomycinscomplex contains a hydroperoxide (-OOH) group bound to cobalt with unusual stability. Under appropriate conditions, cobalt-bleomycins containing other monodentate ligands to cobalt can be formed; fast-atom bombardment mass spectra of such complexes show peaks for cobalt-bleomycin at the expected mass, and also peaks for the intact complexes at the required higher mass.

Original languageEnglish (US)
Pages (from-to)959-966
Number of pages8
JournalBiochemical and Biophysical Research Communications
Volume110
Issue number3
DOIs
StatePublished - Feb 10 1983

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ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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