TY - JOUR
T1 - Identification of a key structural feature of cobalt(III)-bleomycins
T2 - An exogenous ligand (e.g. Hydroperoxide) bound to cobalt
AU - Chang, By Chien Hsing
AU - Dallas, Jerry L.
AU - Meares, Claude F.
PY - 1983/2/10
Y1 - 1983/2/10
N2 - A series of cobalt(III) complexes of the anticancer antibiotic bleomycin has been prepared. Mass spectrometry and enzymatic analysis show that the green cobalt-bleomycinscomplex contains a hydroperoxide (-OOH) group bound to cobalt with unusual stability. Under appropriate conditions, cobalt-bleomycins containing other monodentate ligands to cobalt can be formed; fast-atom bombardment mass spectra of such complexes show peaks for cobalt-bleomycin at the expected mass, and also peaks for the intact complexes at the required higher mass.
AB - A series of cobalt(III) complexes of the anticancer antibiotic bleomycin has been prepared. Mass spectrometry and enzymatic analysis show that the green cobalt-bleomycinscomplex contains a hydroperoxide (-OOH) group bound to cobalt with unusual stability. Under appropriate conditions, cobalt-bleomycins containing other monodentate ligands to cobalt can be formed; fast-atom bombardment mass spectra of such complexes show peaks for cobalt-bleomycin at the expected mass, and also peaks for the intact complexes at the required higher mass.
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U2 - 10.1016/0006-291X(83)91056-2
DO - 10.1016/0006-291X(83)91056-2
M3 - Article
C2 - 6188462
AN - SCOPUS:0020680072
VL - 110
SP - 959
EP - 966
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 3
ER -