Identification of a key structural feature of cobalt(III)-bleomycins: An exogenous ligand (e.g. Hydroperoxide) bound to cobalt

By Chien Hsing Chang, Jerry L. Dallas, Claude F. Meares

Research output: Contribution to journal › Article

42 Citations (Scopus)

Abstract

A series of cobalt(III) complexes of the anticancer antibiotic bleomycin has been prepared. Mass spectrometry and enzymatic analysis show that the green cobalt-bleomycinscomplex contains a hydroperoxide (-OOH) group bound to cobalt with unusual stability. Under appropriate conditions, cobalt-bleomycins containing other monodentate ligands to cobalt can be formed; fast-atom bombardment mass spectra of such complexes show peaks for cobalt-bleomycin at the expected mass, and also peaks for the intact complexes at the required higher mass.

Original languageEnglish (US)
Pages (from-to)959-966
Number of pages8
JournalBiochemical and Biophysical Research Communications
Volume110
Issue number3
DOIs
StatePublished - Feb 10 1983

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Bleomycin
Cobalt
Hydrogen Peroxide
Ligands
Mass spectrometry
Mass Spectrometry
Anti-Bacterial Agents
Atoms
cobalt bleomycin

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Identification of a key structural feature of cobalt(III)-bleomycins : An exogenous ligand (e.g. Hydroperoxide) bound to cobalt. / Chang, By Chien Hsing; Dallas, Jerry L.; Meares, Claude F.

In: Biochemical and Biophysical Research Communications, Vol. 110, No. 3, 10.02.1983, p. 959-966.

Research output: Contribution to journal › Article

Chang, BCH, Dallas, JL & Meares, CF 1983, 'Identification of a key structural feature of cobalt(III)-bleomycins: An exogenous ligand (e.g. Hydroperoxide) bound to cobalt', Biochemical and Biophysical Research Communications, vol. 110, no. 3, pp. 959-966. https://doi.org/10.1016/0006-291X(83)91056-2
Chang BCH, Dallas JL, Meares CF. Identification of a key structural feature of cobalt(III)-bleomycins: An exogenous ligand (e.g. Hydroperoxide) bound to cobalt. Biochemical and Biophysical Research Communications. 1983 Feb 10;110(3):959-966. https://doi.org/10.1016/0006-291X(83)91056-2
Chang, By Chien Hsing ; Dallas, Jerry L. ; Meares, Claude F. / Identification of a key structural feature of cobalt(III)-bleomycins : An exogenous ligand (e.g. Hydroperoxide) bound to cobalt. In: Biochemical and Biophysical Research Communications. 1983 ; Vol. 110, No. 3. pp. 959-966.
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