Identification by next-generation sequencing of Aichivirus B in a calf with enterocolitis and neurologic signs: a cautionary tale

Ana S.D. Moreira, Sarah M. Raabis, Melissa E. Graham, Jennifer M. Dreyfus, Samuel D. Sibley, Jennifer A. Godhardt-Cooper, Kathy L. Kurth, Tony L. Goldberg, Simon F. Peek

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

An 11-d-old Holstein bull calf was presented to the Veterinary Medical Teaching Hospital at the University of Wisconsin–Madison because of a 4-d history of diarrhea and persistent low-grade fever. Initial diagnosis was enteritis caused by Cryptosporidium and rotavirus. During hospitalization, the calf became stuporous and was only responsive to noxious stimuli, with hypotonia of all 4 limbs, tail, head, and neck. A cerebrospinal fluid analysis revealed xanthochromia, with marked lymphocytic pleocytosis, which was suggestive of viral meningitis and/or encephalitis. Aichivirus B, which belongs to the Kobuvirus genus, was tentatively identified in spinal fluid by next-generation DNA sequencing. This virus can affect a multitude of species, including humans and cattle, and has been isolated from both healthy and diarrheic individuals. However, to date, a possible connection with neurologic disease has not been described, to our knowledge.

Original languageEnglish (US)
Pages (from-to)208-211
Number of pages4
JournalJournal of Veterinary Diagnostic Investigation
Volume29
Issue number2
DOIs
StatePublished - Mar 1 2017
Externally publishedYes

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Keywords

  • Bovine
  • contamination
  • diarrhea
  • Kobuvirus

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Moreira, A. S. D., Raabis, S. M., Graham, M. E., Dreyfus, J. M., Sibley, S. D., Godhardt-Cooper, J. A., Kurth, K. L., Goldberg, T. L., & Peek, S. F. (2017). Identification by next-generation sequencing of Aichivirus B in a calf with enterocolitis and neurologic signs: a cautionary tale. Journal of Veterinary Diagnostic Investigation, 29(2), 208-211. https://doi.org/10.1177/1040638716685597