Identification by next-generation sequencing of Aichivirus B in a calf with enterocolitis and neurologic signs: a cautionary tale

Ana S.D. Moreira, Sarah M. Raabis, Melissa E. Graham, Jennifer M. Dreyfus, Samuel D. Sibley, Jennifer A. Godhardt-Cooper, Kathy L. Kurth, Tony L. Goldberg, Simon F. Peek

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

An 11-d-old Holstein bull calf was presented to the Veterinary Medical Teaching Hospital at the University of Wisconsin–Madison because of a 4-d history of diarrhea and persistent low-grade fever. Initial diagnosis was enteritis caused by Cryptosporidium and rotavirus. During hospitalization, the calf became stuporous and was only responsive to noxious stimuli, with hypotonia of all 4 limbs, tail, head, and neck. A cerebrospinal fluid analysis revealed xanthochromia, with marked lymphocytic pleocytosis, which was suggestive of viral meningitis and/or encephalitis. Aichivirus B, which belongs to the Kobuvirus genus, was tentatively identified in spinal fluid by next-generation DNA sequencing. This virus can affect a multitude of species, including humans and cattle, and has been isolated from both healthy and diarrheic individuals. However, to date, a possible connection with neurologic disease has not been described, to our knowledge.

Original languageEnglish (US)
Pages (from-to)208-211
Number of pages4
JournalJournal of Veterinary Diagnostic Investigation
Volume29
Issue number2
DOIs
StatePublished - Mar 1 2017
Externally publishedYes

Fingerprint

Kobuvirus
Viral Meningitis
Viral Encephalitis
Enterocolitis
enterocolitis
Cryptosporidium
Muscle Hypotonia
Enteritis
Rotavirus
Leukocytosis
Neurologic Manifestations
Nervous System Diseases
DNA Sequence Analysis
nervous system
Teaching Hospitals
Cerebrospinal Fluid
Diarrhea
Hospitalization
Fever
Neck

Keywords

  • Bovine
  • contamination
  • diarrhea
  • Kobuvirus

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Moreira, A. S. D., Raabis, S. M., Graham, M. E., Dreyfus, J. M., Sibley, S. D., Godhardt-Cooper, J. A., ... Peek, S. F. (2017). Identification by next-generation sequencing of Aichivirus B in a calf with enterocolitis and neurologic signs: a cautionary tale. Journal of Veterinary Diagnostic Investigation, 29(2), 208-211. https://doi.org/10.1177/1040638716685597

Identification by next-generation sequencing of Aichivirus B in a calf with enterocolitis and neurologic signs : a cautionary tale. / Moreira, Ana S.D.; Raabis, Sarah M.; Graham, Melissa E.; Dreyfus, Jennifer M.; Sibley, Samuel D.; Godhardt-Cooper, Jennifer A.; Kurth, Kathy L.; Goldberg, Tony L.; Peek, Simon F.

In: Journal of Veterinary Diagnostic Investigation, Vol. 29, No. 2, 01.03.2017, p. 208-211.

Research output: Contribution to journalArticle

Moreira, Ana S.D. ; Raabis, Sarah M. ; Graham, Melissa E. ; Dreyfus, Jennifer M. ; Sibley, Samuel D. ; Godhardt-Cooper, Jennifer A. ; Kurth, Kathy L. ; Goldberg, Tony L. ; Peek, Simon F. / Identification by next-generation sequencing of Aichivirus B in a calf with enterocolitis and neurologic signs : a cautionary tale. In: Journal of Veterinary Diagnostic Investigation. 2017 ; Vol. 29, No. 2. pp. 208-211.
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