Identification and pathogenicity of a natural reassortant between a very virulent serotype 1 infectious bursal disease virus (IBDV) and a serotype 2 IBDV

Daral J. Jackwood, Susan E. Sommer-Wagner, Beate Crossley, Simone Stoute, Peter R. Woolcock, Bruce R. Charlton

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

Infectious bursal disease virus (IBDV) causes an economically important, immunosuppressive disease in chickens. There are two serotypes of the virus that contain a bi-segmented double-stranded RNA genome. In December 2008, the first very virulent (vv)IBDV was identified in California, USA and in 2009 we isolated reassortant viruses in two different locations. Genome segment A of these reassortants was typical of vvIBDV serotype 1 but genome segment B was most similar to IBDV serotype 2. The CA-K785 reassortant caused 20% mortality in chickens but no morbidity or mortality in commercial turkey poults despite being infectious. There have been previous reports of natural reassortants between vvIBDV and other serotype 1 strains, but a natural reassortant between IBDV serotypes 1 and 2 has not been described. The apparent reassorting of California vvIBDV with an endemic serotype 2 virus indicates a common host and suggests vvIBDV may have entered California earlier than originally thought.

Original languageEnglish (US)
Pages (from-to)98-105
Number of pages8
JournalVirology
Volume420
Issue number2
DOIs
StatePublished - Nov 25 2011

Keywords

  • Birnavirus
  • Infectious bursal disease
  • Infectious bursal disease virus
  • Pathogenicity
  • Reassortant
  • Serotypes 1 and 2

ASJC Scopus subject areas

  • Virology

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