Abstract
A cDNA clone encoding a new member of the type I serine/threonine kinase receptors of the TGF-β/BMP superfamily was isolated from a rat prostate cDNA library. The predicted sequence of the encoded protein is 493 amino acids with a molecular weight of 55 kDa. It contains a putative cysteine rich extracellular domain, a transmembrane domain, a conserved type I receptor GS domain and a cytoplasmic serine/threonine kinase domain. The kinase domain shares 80% homology with that of ALK-4 and ALK-5 whose ligands are activin and TGF-β. Northern blot analysis revealed that this prostate serine/threonine kinase receptor I (PSKR-I) is highly expressed in rat dorsolateral prostate, coagulating gland (anterior prostate), cerebellum and adipose tissue.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 993-1001 |
| Number of pages | 9 |
| Journal | Biochemistry and Molecular Biology International |
| Volume | 40 |
| Issue number | 5 |
| State | Published - 1996 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biochemistry
- Genetics
- Molecular Biology