Identification and characterization of novel immunomodulatory bursal-derived pentapeptide-II (BPP-II)

Xiuli Feng, Qing Tao Liu, Rui Bing Cao, Bin Zhou, Zhi Yong Ma, Wen Lei Deng, Jian Chao Wei, Ya Feng Qiu, Fang Quan Wang, Jin Yan Gu, Feng Juan Wang, Qi Sheng Zheng, Hassan Ishag, Pu Yan Chen

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


The bursa of Fabricius, the acknowledged central humoral immune organ, plays a vital role inBlymphocyte differentiation. However, there are few reports of the molecular basis of the mechanism on immune induction and potential antitumor activity of bursal-derived peptides. In this paper, a novel bursalderived pentapeptide-II (BPP-II, MTLTG) was isolated and exerted immunomodulatory functions on antibody responses in vitro. Gene microarray analyses demonstrated that BPP-II regulated expression of 2478 genes in a mouse-derived hybridoma cell line. Immune-related gene ontology functional procedures were employed for further functional analysis. Furthermore, the majority of BPP-II-regulated pathways were associated with immune responses and tumor processes. Moreover, BPP-II exhibited immunomodulatory effects on antigen-specific immune responses in vivo, including enhancement of avian influenza virus (H9N2 subtype)-specific antibody and cytokine production and modification of T cell immunophenotypes and lymphocyte proliferation. Finally, BPP-II triggered p53 expression and stabilization and selectively inhibited tumor cell proliferation. These data identified the multifunctional factor, BPP-II, as a novel biomaterial representing an important linking between the humoral central immune system and immune induction, including antitumor. Information generated in this study elucidates further the mechanisms involved in humoral immune system and represents the potential basis of effective immunotherapeutic strategies for treating human tumors and immune improvement.

Original languageEnglish (US)
Pages (from-to)3798-3807
Number of pages10
JournalJournal of Biological Chemistry
Issue number6
StatePublished - Feb 3 2012
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology


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