Identical progression of juvenile hereditary nephronophthisis in monozygotic twins

Sudesh P Makker, Warren E. Grupe, Eugene Perrin, Walter Heymann

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


A pair of monozygotic twins with juvenile hereditary nephronophthisis was studiedfor nearly ten years. Astonishing similarity was observed in the clinical course, progression, and histopathology of the disease. In a review of the natural history of various diseases in identical twins it was noted that diseases of infectious or immunologic pathogenesis usually do not follow identical courses. Diseases due to inborn errors of metabolism are more likely to do so. It is suggested that juvenile hereditary nephronophthisis might be due to an inborn error of metabolism.

Original languageEnglish (US)
Pages (from-to)773-779
Number of pages7
JournalThe Journal of Pediatrics
Issue number5
StatePublished - 1973
Externally publishedYes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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