Ideal observer comparison between tomographic and projection x-ray images of the breast

John M Boone, Nathan J. Packard, Craig K. Abbey

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

The image data from 348 breast CT studies performed on patient volunteers in a Phase II clinical trial were used in a pre-whitened matched filter (PWMF) model observer study. This computer-based investigation simulated the addition of spherical lesions of various diameters to the breast data sets, and a series of images with different slice thicknesses ranging from 0.3 mm to 44 mm were created by voxel averaging. The PWMF was tailored to each slice thickness, and signal known exactly receiver operating characteristic analysis was performed. A total of 1000 lesions and "non-lesions" were simulated for each diameter on each breast data set. Receiver operating characteristic (ROC) curve analysis was performed, and sensitivity at 95% specificity was computed. Thin slice imaging as with breast CT demonstrated significantly better sensitivity than thick slice images as with mammography, with improvements in sensitivity ranging from 5% to 50%.

Original languageEnglish (US)
Title of host publicationLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Pages591-597
Number of pages7
Volume6136 LNCS
DOIs
StatePublished - 2010
Event10th International Workshop on Digital Mammography, IWDM 2010 - Girona, Catalonia, Spain
Duration: Jun 16 2010Jun 18 2010

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume6136 LNCS
ISSN (Print)03029743
ISSN (Electronic)16113349

Other

Other10th International Workshop on Digital Mammography, IWDM 2010
CountrySpain
CityGirona, Catalonia
Period6/16/106/18/10

Keywords

  • Breast CT
  • Ideal Observers
  • Receiver Operating Characteristic Curves

ASJC Scopus subject areas

  • Computer Science(all)
  • Theoretical Computer Science

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    Boone, J. M., Packard, N. J., & Abbey, C. K. (2010). Ideal observer comparison between tomographic and projection x-ray images of the breast. In Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) (Vol. 6136 LNCS, pp. 591-597). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 6136 LNCS). https://doi.org/10.1007/978-3-642-13666-5_80