Abstract
Various methods of continuous intracranial pressure (ICP) monitoring during experimental procedures in the rat have been described. However, no systematic comparison of ICP monitoring in the ventricle, brain parenchyma, and cisterna magna has been reported. Since accurate and reliable ICP measurements are important in experimental models of traumatic brain injury, the present study was conducted to compare simultaneous ICP measurements from ventricular, cisterna magna, and intraparenchymal monitors during ICP changes. Subdural hematoma was produced by infusion of 0.3 ml of autologous blood into the subdural space over 6 min. The ventricular and the intraparenchymal fiberoptic catheter produced reliable and comparable pressure recordings, that did not statistically differ (p = 0.4), throughout the one hour monitoring time. In contrast, the cisterna magna catheter was less reliable and produced significantly lower readings throughout the monitoring time (p < 0.001). The intraparenchymal device produced greater cortical damage than the ventricular catheter. In conclusion, ventricular ICP monitoring is the preferred method under these circumstances, since it is accurate and induces least brain damage.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1095-1102 |
| Number of pages | 8 |
| Journal | Journal of Neurotrauma |
| Volume | 16 |
| Issue number | 11 |
| State | Published - Nov 1999 |
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Keywords
- Intracranial pressure monitoring
- Rat
- Subdural hematoma
ASJC Scopus subject areas
- Clinical Neurology
- Neuroscience(all)
Cite this
ICP monitoring in the rat : Comparison of monitoring in the ventricle, brain parenchyma, and cistema magna. / Zwienenberg-Lee, Marike; Gong, Qin Zhi; Lee, Lillian L.; Berman, Robert F; Lyeth, Bruce G.
In: Journal of Neurotrauma, Vol. 16, No. 11, 11.1999, p. 1095-1102.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - ICP monitoring in the rat
T2 - Comparison of monitoring in the ventricle, brain parenchyma, and cistema magna
AU - Zwienenberg-Lee, Marike
AU - Gong, Qin Zhi
AU - Lee, Lillian L.
AU - Berman, Robert F
AU - Lyeth, Bruce G
PY - 1999/11
Y1 - 1999/11
N2 - Various methods of continuous intracranial pressure (ICP) monitoring during experimental procedures in the rat have been described. However, no systematic comparison of ICP monitoring in the ventricle, brain parenchyma, and cisterna magna has been reported. Since accurate and reliable ICP measurements are important in experimental models of traumatic brain injury, the present study was conducted to compare simultaneous ICP measurements from ventricular, cisterna magna, and intraparenchymal monitors during ICP changes. Subdural hematoma was produced by infusion of 0.3 ml of autologous blood into the subdural space over 6 min. The ventricular and the intraparenchymal fiberoptic catheter produced reliable and comparable pressure recordings, that did not statistically differ (p = 0.4), throughout the one hour monitoring time. In contrast, the cisterna magna catheter was less reliable and produced significantly lower readings throughout the monitoring time (p < 0.001). The intraparenchymal device produced greater cortical damage than the ventricular catheter. In conclusion, ventricular ICP monitoring is the preferred method under these circumstances, since it is accurate and induces least brain damage.
AB - Various methods of continuous intracranial pressure (ICP) monitoring during experimental procedures in the rat have been described. However, no systematic comparison of ICP monitoring in the ventricle, brain parenchyma, and cisterna magna has been reported. Since accurate and reliable ICP measurements are important in experimental models of traumatic brain injury, the present study was conducted to compare simultaneous ICP measurements from ventricular, cisterna magna, and intraparenchymal monitors during ICP changes. Subdural hematoma was produced by infusion of 0.3 ml of autologous blood into the subdural space over 6 min. The ventricular and the intraparenchymal fiberoptic catheter produced reliable and comparable pressure recordings, that did not statistically differ (p = 0.4), throughout the one hour monitoring time. In contrast, the cisterna magna catheter was less reliable and produced significantly lower readings throughout the monitoring time (p < 0.001). The intraparenchymal device produced greater cortical damage than the ventricular catheter. In conclusion, ventricular ICP monitoring is the preferred method under these circumstances, since it is accurate and induces least brain damage.
KW - Intracranial pressure monitoring
KW - Rat
KW - Subdural hematoma
UR - http://www.scopus.com/inward/record.url?scp=0032739946&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032739946&partnerID=8YFLogxK
M3 - Article
C2 - 10595825
AN - SCOPUS:0032739946
VL - 16
SP - 1095
EP - 1102
JO - Journal of Neurotrauma
JF - Journal of Neurotrauma
SN - 0897-7151
IS - 11
ER -