Abstract
Purpose of Review: We reviewed recent literature on oxygen sensing in osteogenic cells and its contribution to development of a skeletal phenotype, the coupling of osteogenesis with angiogenesis and integration of hypoxia into canonical Wnt signaling, and opportunities to manipulate oxygen sensing to promote skeletal repair. Recent Findings: Oxygen sensing in osteocytes can confer a high bone mass phenotype in murine models; common and unique targets of HIF-1α and HIF-2α and lineage-specific deletion of oxygen sensing machinery suggest differentia utilization and requirement of HIF-α proteins in the differentiation from mesenchymal stem cell to osteoblast to osteocyte; oxygen-dependent but HIF-α-independent signaling may contribute to observed skeletal phenotypes. Summary: Manipulating oxygen sensing machinery in osteogenic cells influences skeletal phenotype through angiogenesis-dependent and angiogenesis-independent pathways and involves HIF-1α, HIF-2α, or both proteins. Clinically, an FDA-approved iron chelator promotes angiogenesis and osteogenesis, thereby enhancing the rate of fracture repair.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 26-35 |
| Number of pages | 10 |
| Journal | Current Osteoporosis Reports |
| Volume | 17 |
| Issue number | 1 |
| DOIs | |
| State | Published - Feb 15 2019 |
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Keywords
- Bone
- HIF
- Hypoxia
- Sclerostin
- Wnt
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
Cite this
Hypoxia Signaling in the Skeleton : Implications for Bone Health. / Yellowley-genetos, Clare E; Genetos, Damian C.
In: Current Osteoporosis Reports, Vol. 17, No. 1, 15.02.2019, p. 26-35.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Hypoxia Signaling in the Skeleton
T2 - Implications for Bone Health
AU - Yellowley-genetos, Clare E
AU - Genetos, Damian C
PY - 2019/2/15
Y1 - 2019/2/15
N2 - Purpose of Review: We reviewed recent literature on oxygen sensing in osteogenic cells and its contribution to development of a skeletal phenotype, the coupling of osteogenesis with angiogenesis and integration of hypoxia into canonical Wnt signaling, and opportunities to manipulate oxygen sensing to promote skeletal repair. Recent Findings: Oxygen sensing in osteocytes can confer a high bone mass phenotype in murine models; common and unique targets of HIF-1α and HIF-2α and lineage-specific deletion of oxygen sensing machinery suggest differentia utilization and requirement of HIF-α proteins in the differentiation from mesenchymal stem cell to osteoblast to osteocyte; oxygen-dependent but HIF-α-independent signaling may contribute to observed skeletal phenotypes. Summary: Manipulating oxygen sensing machinery in osteogenic cells influences skeletal phenotype through angiogenesis-dependent and angiogenesis-independent pathways and involves HIF-1α, HIF-2α, or both proteins. Clinically, an FDA-approved iron chelator promotes angiogenesis and osteogenesis, thereby enhancing the rate of fracture repair.
AB - Purpose of Review: We reviewed recent literature on oxygen sensing in osteogenic cells and its contribution to development of a skeletal phenotype, the coupling of osteogenesis with angiogenesis and integration of hypoxia into canonical Wnt signaling, and opportunities to manipulate oxygen sensing to promote skeletal repair. Recent Findings: Oxygen sensing in osteocytes can confer a high bone mass phenotype in murine models; common and unique targets of HIF-1α and HIF-2α and lineage-specific deletion of oxygen sensing machinery suggest differentia utilization and requirement of HIF-α proteins in the differentiation from mesenchymal stem cell to osteoblast to osteocyte; oxygen-dependent but HIF-α-independent signaling may contribute to observed skeletal phenotypes. Summary: Manipulating oxygen sensing machinery in osteogenic cells influences skeletal phenotype through angiogenesis-dependent and angiogenesis-independent pathways and involves HIF-1α, HIF-2α, or both proteins. Clinically, an FDA-approved iron chelator promotes angiogenesis and osteogenesis, thereby enhancing the rate of fracture repair.
KW - Bone
KW - HIF
KW - Hypoxia
KW - Sclerostin
KW - Wnt
UR - http://www.scopus.com/inward/record.url?scp=85061228640&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85061228640&partnerID=8YFLogxK
U2 - 10.1007/s11914-019-00500-6
DO - 10.1007/s11914-019-00500-6
M3 - Review article
C2 - 30725321
AN - SCOPUS:85061228640
VL - 17
SP - 26
EP - 35
JO - Foodborne Pathogens and Disease
JF - Foodborne Pathogens and Disease
SN - 1744-165X
IS - 1
ER -