Abstract
Purpose of Review: We reviewed recent literature on oxygen sensing in osteogenic cells and its contribution to development of a skeletal phenotype, the coupling of osteogenesis with angiogenesis and integration of hypoxia into canonical Wnt signaling, and opportunities to manipulate oxygen sensing to promote skeletal repair. Recent Findings: Oxygen sensing in osteocytes can confer a high bone mass phenotype in murine models; common and unique targets of HIF-1α and HIF-2α and lineage-specific deletion of oxygen sensing machinery suggest differentia utilization and requirement of HIF-α proteins in the differentiation from mesenchymal stem cell to osteoblast to osteocyte; oxygen-dependent but HIF-α-independent signaling may contribute to observed skeletal phenotypes. Summary: Manipulating oxygen sensing machinery in osteogenic cells influences skeletal phenotype through angiogenesis-dependent and angiogenesis-independent pathways and involves HIF-1α, HIF-2α, or both proteins. Clinically, an FDA-approved iron chelator promotes angiogenesis and osteogenesis, thereby enhancing the rate of fracture repair.
Original language | English (US) |
---|---|
Pages (from-to) | 26-35 |
Number of pages | 10 |
Journal | Current Osteoporosis Reports |
Volume | 17 |
Issue number | 1 |
DOIs | |
State | Published - Feb 15 2019 |
Keywords
- Bone
- HIF
- Hypoxia
- Sclerostin
- Wnt
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism