Hypovitaminosis D in delirium: A retrospective cross-sectional study

Jennifer Ford, Ana Hategan, James A. Bourgeois, Daniel K. Tisi, Glen Xiong

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Background As vitamin D may have a neuroprotective effect, the authors studied the association of biomarkers of vitamin D status and delirium to see if low vitamin D status was common in delirium cases. Methods Biochemical measures of vitamin D (25-hydroxyvitamin D [25-OHD]) and calcium metabolism were used in this retrospective cross-sectional analysis of adult in-patients with delirium, admitted at three Canadian academic hospitals from January 2011 to July 2012. Primary outcome was to determine estimates of the prevalence of hypovitaminosis D in this group in whom vitamin D was checked. Results Seventy-one (5.8%) out of 1,232 delirium inpatients had their vitamin D measured. Thirty-nine (55%) showed vitamin D insufficiency (25-OHD of 25-75 nmol/L) and 8 (11%) showed vitamin D deficiency (25-OHD < 25 nmol/L). Mean serum 25-OHD levels were lower in males (57.1±7.7 nmol/L) than in females (78.2±6.1 nmol/L), p = .01, even when controlled for age and season. Men were younger than the women (74.4±2.3 vs. 82.4±1.7, p = .005). Mean age was 78.7±1.5 years, and 33 (47%) were male. Conclusions Although vitamin D is rarely checked during delirium workup and/or management, high rates of hypovitaminosis D were found to be common in the delirium in-patients in whom it was checked. Larger studies would be needed to estimate the prevalence of hypovitaminosis D in delirium and whether hypovitaminosis D plays a role in the pathogenesis of delirium.

Original languageEnglish (US)
Pages (from-to)186-191
Number of pages6
JournalCanadian Geriatrics Journal
Volume16
Issue number4
DOIs
StatePublished - Dec 1 2013

Keywords

  • Acute care
  • Acute in-patient
  • Delirium
  • Vitamin D
  • Vitamin D insufficiency

ASJC Scopus subject areas

  • Gerontology
  • Geriatrics and Gerontology

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    Ford, J., Hategan, A., Bourgeois, J. A., Tisi, D. K., & Xiong, G. (2013). Hypovitaminosis D in delirium: A retrospective cross-sectional study. Canadian Geriatrics Journal, 16(4), 186-191. https://doi.org/10.5770/cgj.16.79