Hypothermia as an adjunctive treatment for severe bacterial meningitis

Jose E. Irazuzta, Robert Pretzlaff, Mark Rowin, Kevin Milam, Frank P. Zemlan, Basilia Zingarelli

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Brain injury due to bacterial meningitis results in a high mortality rate and significant neurologic sequelae in survivors. The objective of this study was to determine if the application of moderate hypothermia shortly after the administration of antibiotics would attenuate the inflammatory response and increase in intracranial pressure that occurs in meningitis. For this study we used a rabbit model of severe Group B streptococcal meningitis. The first component of this study evaluated the effects of hypothermia on blood-brain barrier function and markers of inflammation in meningitic animals. The second part of the study evaluated the effects of hypothermia on intracranial pressure, cerebral perfusion pressure and brain edema. This study demonstrates that the use of hypothermia preserves CSF/serum glucose ratio, decreases CSF protein and nitric oxide and attenuates myeloperoxidase activity in brain tissue. In the second part of this study we show a decrease in intracranial pressure, an improvement in cerebral perfusion pressure and a decrease in cerebral edema in hypothermic meningitic animals. We conclude that in the treatment of severe bacterial meningitis, the application of moderate hypothermia initiated shortly after antibiotic therapy improves short-term physiologic measures associated with brain injury. Copyright (C) 2000 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)88-97
Number of pages10
JournalBrain Research
Volume881
Issue number1
DOIs
StatePublished - Oct 20 2000
Externally publishedYes

Fingerprint

Bacterial Meningitides
Hypothermia
Cerebrovascular Circulation
Brain Edema
Intracranial Pressure
Meningitis
Brain Injuries
Anti-Bacterial Agents
Therapeutics
Intracranial Hypertension
Blood-Brain Barrier
Nervous System
Peroxidase
Survivors
Nitric Oxide
Rabbits
Inflammation
Glucose
Mortality
Brain

Keywords

  • Cerebral perfusion pressure
  • Cleaved Tau protein
  • Hypothermia
  • Inflammation
  • Intracranial pressure
  • Meningitis

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Irazuzta, J. E., Pretzlaff, R., Rowin, M., Milam, K., Zemlan, F. P., & Zingarelli, B. (2000). Hypothermia as an adjunctive treatment for severe bacterial meningitis. Brain Research, 881(1), 88-97. https://doi.org/10.1016/S0006-8993(00)02894-8

Hypothermia as an adjunctive treatment for severe bacterial meningitis. / Irazuzta, Jose E.; Pretzlaff, Robert; Rowin, Mark; Milam, Kevin; Zemlan, Frank P.; Zingarelli, Basilia.

In: Brain Research, Vol. 881, No. 1, 20.10.2000, p. 88-97.

Research output: Contribution to journalArticle

Irazuzta, JE, Pretzlaff, R, Rowin, M, Milam, K, Zemlan, FP & Zingarelli, B 2000, 'Hypothermia as an adjunctive treatment for severe bacterial meningitis', Brain Research, vol. 881, no. 1, pp. 88-97. https://doi.org/10.1016/S0006-8993(00)02894-8
Irazuzta JE, Pretzlaff R, Rowin M, Milam K, Zemlan FP, Zingarelli B. Hypothermia as an adjunctive treatment for severe bacterial meningitis. Brain Research. 2000 Oct 20;881(1):88-97. https://doi.org/10.1016/S0006-8993(00)02894-8
Irazuzta, Jose E. ; Pretzlaff, Robert ; Rowin, Mark ; Milam, Kevin ; Zemlan, Frank P. ; Zingarelli, Basilia. / Hypothermia as an adjunctive treatment for severe bacterial meningitis. In: Brain Research. 2000 ; Vol. 881, No. 1. pp. 88-97.
@article{41c72e502c714f68abe6ab0d070194b0,
title = "Hypothermia as an adjunctive treatment for severe bacterial meningitis",
abstract = "Brain injury due to bacterial meningitis results in a high mortality rate and significant neurologic sequelae in survivors. The objective of this study was to determine if the application of moderate hypothermia shortly after the administration of antibiotics would attenuate the inflammatory response and increase in intracranial pressure that occurs in meningitis. For this study we used a rabbit model of severe Group B streptococcal meningitis. The first component of this study evaluated the effects of hypothermia on blood-brain barrier function and markers of inflammation in meningitic animals. The second part of the study evaluated the effects of hypothermia on intracranial pressure, cerebral perfusion pressure and brain edema. This study demonstrates that the use of hypothermia preserves CSF/serum glucose ratio, decreases CSF protein and nitric oxide and attenuates myeloperoxidase activity in brain tissue. In the second part of this study we show a decrease in intracranial pressure, an improvement in cerebral perfusion pressure and a decrease in cerebral edema in hypothermic meningitic animals. We conclude that in the treatment of severe bacterial meningitis, the application of moderate hypothermia initiated shortly after antibiotic therapy improves short-term physiologic measures associated with brain injury. Copyright (C) 2000 Elsevier Science B.V.",
keywords = "Cerebral perfusion pressure, Cleaved Tau protein, Hypothermia, Inflammation, Intracranial pressure, Meningitis",
author = "Irazuzta, {Jose E.} and Robert Pretzlaff and Mark Rowin and Kevin Milam and Zemlan, {Frank P.} and Basilia Zingarelli",
year = "2000",
month = "10",
day = "20",
doi = "10.1016/S0006-8993(00)02894-8",
language = "English (US)",
volume = "881",
pages = "88--97",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - Hypothermia as an adjunctive treatment for severe bacterial meningitis

AU - Irazuzta, Jose E.

AU - Pretzlaff, Robert

AU - Rowin, Mark

AU - Milam, Kevin

AU - Zemlan, Frank P.

AU - Zingarelli, Basilia

PY - 2000/10/20

Y1 - 2000/10/20

N2 - Brain injury due to bacterial meningitis results in a high mortality rate and significant neurologic sequelae in survivors. The objective of this study was to determine if the application of moderate hypothermia shortly after the administration of antibiotics would attenuate the inflammatory response and increase in intracranial pressure that occurs in meningitis. For this study we used a rabbit model of severe Group B streptococcal meningitis. The first component of this study evaluated the effects of hypothermia on blood-brain barrier function and markers of inflammation in meningitic animals. The second part of the study evaluated the effects of hypothermia on intracranial pressure, cerebral perfusion pressure and brain edema. This study demonstrates that the use of hypothermia preserves CSF/serum glucose ratio, decreases CSF protein and nitric oxide and attenuates myeloperoxidase activity in brain tissue. In the second part of this study we show a decrease in intracranial pressure, an improvement in cerebral perfusion pressure and a decrease in cerebral edema in hypothermic meningitic animals. We conclude that in the treatment of severe bacterial meningitis, the application of moderate hypothermia initiated shortly after antibiotic therapy improves short-term physiologic measures associated with brain injury. Copyright (C) 2000 Elsevier Science B.V.

AB - Brain injury due to bacterial meningitis results in a high mortality rate and significant neurologic sequelae in survivors. The objective of this study was to determine if the application of moderate hypothermia shortly after the administration of antibiotics would attenuate the inflammatory response and increase in intracranial pressure that occurs in meningitis. For this study we used a rabbit model of severe Group B streptococcal meningitis. The first component of this study evaluated the effects of hypothermia on blood-brain barrier function and markers of inflammation in meningitic animals. The second part of the study evaluated the effects of hypothermia on intracranial pressure, cerebral perfusion pressure and brain edema. This study demonstrates that the use of hypothermia preserves CSF/serum glucose ratio, decreases CSF protein and nitric oxide and attenuates myeloperoxidase activity in brain tissue. In the second part of this study we show a decrease in intracranial pressure, an improvement in cerebral perfusion pressure and a decrease in cerebral edema in hypothermic meningitic animals. We conclude that in the treatment of severe bacterial meningitis, the application of moderate hypothermia initiated shortly after antibiotic therapy improves short-term physiologic measures associated with brain injury. Copyright (C) 2000 Elsevier Science B.V.

KW - Cerebral perfusion pressure

KW - Cleaved Tau protein

KW - Hypothermia

KW - Inflammation

KW - Intracranial pressure

KW - Meningitis

UR - http://www.scopus.com/inward/record.url?scp=0034693387&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034693387&partnerID=8YFLogxK

U2 - 10.1016/S0006-8993(00)02894-8

DO - 10.1016/S0006-8993(00)02894-8

M3 - Article

C2 - 11033098

AN - SCOPUS:0034693387

VL - 881

SP - 88

EP - 97

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 1

ER -