Hypothalamic melanin-concentrating hormone and estrogen-induced weight loss

P. Mystkowski, R. J. Seeley, T. M. Hahn, D. G. Baskin, Peter J Havel, A. M. Matsumoto, C. W. Wilkinson, K. Peacock-Kinzig, K. A. Blake, M. W. Schwartz

Research output: Contribution to journalArticlepeer-review

64 Scopus citations


Melanin-concentrating hormone (MCH) is an orexigenic neuropeptide produced by neurons of the lateral hypothalamic area (LHA). Because genetic MCH deficiency induces hypophagia and loss of body fat, we hypothesized that MCH neurons may represent a specific LHA pathway that, when inhibited, contributes to the pathogenesis of certain anorexia syndromes. To test this hypothesis, we measured behavioral, hormonal, and hypothalamic neuropeptide responses in two models of hyperestrogenemia in male rats, a highly reproducible anorexia paradigm. Whereas estrogen-induced weight loss engaged multiple systems that normally favor recovery of lost weight, the expected increase of MCH mRNA expression induced by energy restriction was selectively and completely abolished. These findings identify MCH neurons as specific targets of estrogen action and suggest that inhibition of these neurons may contribute to the hypophagic effect of estrogen.

Original languageEnglish (US)
Pages (from-to)8637-8642
Number of pages6
JournalJournal of Neuroscience
Issue number22
StatePublished - Nov 15 2000
Externally publishedYes


  • Anorexia
  • Body weight
  • Energy balance
  • Estrogen
  • Lateral hypothalamus
  • MCH
  • Pair-feeding

ASJC Scopus subject areas

  • Neuroscience(all)


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