Hypophosphatemia in cats after renal transplantation

Erin R. Paster, Margo L. Mehl, Philip H Kass, Clare R. Gregory

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective To report the prevalence of hypophosphatemia after renal transplantation in a historical cohort of cats. Design Case series. Animals Cats (n=86) that received a renal allograft. Methods Medical records (January 200-June 2006) were reviewed. Signalment, clinical signs, pre- and postoperative diet, pre- and postoperative clinicopathologic variables, renal histopathology, and outcome were retrieved. Prevalence, onset, duration, treatment and associated clinical signs of hypophosphatemia were recorded. A χ2 test was used to compare hemolysis frequency between cats with normal serum phosphorus concentration or a single spurious low serum phosphorus concentration for <24 hours duration (group 1) and confirmed hypophosphatemia for >24 hours (group 2). A Cox proportional hazards model was used to evaluate the effects of hypophosphatemia on survival while controlling for other potentially confounding variables (age, sex, weight, body condition score, and pre- and 24 hours postoperative clinicopathologic variables). Results Eighty-six cats (mean age, 7.7 years) were identified. Hypophosphatemia occurred in 32 cats (37%), with a median onset of 2 days and median duration of 4 days. Treatment was initiated in 48 (56%) of hypophosphatemic cats. Survival and hemolysis frequency was not significantly different between groups, and no risk factors were identified. Conclusion Hypophosphatemia occurs in cats after renal transplantation and does not affect survival. Clinical Relevance The clinical importance of hypophosphatemia in renal transplant recipients remains unknown.

Original languageEnglish (US)
Pages (from-to)983-989
Number of pages7
JournalVeterinary Surgery
Volume38
Issue number8
DOIs
StatePublished - Dec 2009

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Hypophosphatemia
kidney transplant
Kidney Transplantation
Cats
cats
hemolysis
Hemolysis
Kidney
Phosphorus
Survival
kidneys
phosphorus
allografting
duration
Confounding Factors (Epidemiology)
Serum
Proportional Hazards Models
histopathology
Medical Records
body condition

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Hypophosphatemia in cats after renal transplantation. / Paster, Erin R.; Mehl, Margo L.; Kass, Philip H; Gregory, Clare R.

In: Veterinary Surgery, Vol. 38, No. 8, 12.2009, p. 983-989.

Research output: Contribution to journalArticle

Paster, Erin R. ; Mehl, Margo L. ; Kass, Philip H ; Gregory, Clare R. / Hypophosphatemia in cats after renal transplantation. In: Veterinary Surgery. 2009 ; Vol. 38, No. 8. pp. 983-989.
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N2 - Objective To report the prevalence of hypophosphatemia after renal transplantation in a historical cohort of cats. Design Case series. Animals Cats (n=86) that received a renal allograft. Methods Medical records (January 200-June 2006) were reviewed. Signalment, clinical signs, pre- and postoperative diet, pre- and postoperative clinicopathologic variables, renal histopathology, and outcome were retrieved. Prevalence, onset, duration, treatment and associated clinical signs of hypophosphatemia were recorded. A χ2 test was used to compare hemolysis frequency between cats with normal serum phosphorus concentration or a single spurious low serum phosphorus concentration for <24 hours duration (group 1) and confirmed hypophosphatemia for >24 hours (group 2). A Cox proportional hazards model was used to evaluate the effects of hypophosphatemia on survival while controlling for other potentially confounding variables (age, sex, weight, body condition score, and pre- and 24 hours postoperative clinicopathologic variables). Results Eighty-six cats (mean age, 7.7 years) were identified. Hypophosphatemia occurred in 32 cats (37%), with a median onset of 2 days and median duration of 4 days. Treatment was initiated in 48 (56%) of hypophosphatemic cats. Survival and hemolysis frequency was not significantly different between groups, and no risk factors were identified. Conclusion Hypophosphatemia occurs in cats after renal transplantation and does not affect survival. Clinical Relevance The clinical importance of hypophosphatemia in renal transplant recipients remains unknown.

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