Hyponatremia associated with desmopressin for the treatment of nocturnal polyuria

Alan W Shindel, Gary Tobin, Carl Klutke

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Desmopressin diacetate arginine vasopressin (DDAVP) is a synthetic analogue of the mammalian arginine vasopressin used in the treatment of central diabetes insipidus, bleeding disorders, and incontinence. The primary adverse reaction associated with DDAVP is hypotonic hyponatremia. Hyponatremia has been reported in adults treated with DDAVP for Von Willebrand's disease and hemophilia and in children treated for enuresis, but as yet few cases of hyponatremia developing in enuretic adults treated with DDAVP have been reported. We report the cases of two elderly women taking DDAVP for nocturnal polyuria who developed severe hyponatremia. One patient died in the hospital.

Original languageEnglish (US)
JournalUrology
Volume60
Issue number2
StatePublished - 2002
Externally publishedYes

Fingerprint

Polyuria
Deamino Arginine Vasopressin
Hyponatremia
Arginine Vasopressin
Therapeutics
Neurogenic Diabetes Insipidus
Enuresis
von Willebrand Diseases
Hemophilia A
Hemorrhage

ASJC Scopus subject areas

  • Urology

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Hyponatremia associated with desmopressin for the treatment of nocturnal polyuria. / Shindel, Alan W; Tobin, Gary; Klutke, Carl.

In: Urology, Vol. 60, No. 2, 2002.

Research output: Contribution to journalArticle

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