Hypomagnesemia in Brachycephalic Dogs

M. S. Mellema, G. L. Hoareau

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: Brachycephalic dogs are at risk for arterial hypertension and obstructive sleep apnea, which are both associated with chronic magnesium (Mg) depletion. Hypothesis/Objectives: To compare the period prevalence of hypomagnesemia between Boxers and Bulldogs presented to a referral teaching hospital. To screen a group of Bulldogs for evidence of hypomagnesemia, and to obtain pilot data regarding the utility of parenteral Mg tolerance testing (PMgTT) in the diagnosis of whole-body Mg deficiency. Animals: Chemistry laboratory submissions were retrospectively analyzed for serum total Mg (tMg) in Boxers and Bulldogs. Prospectively, 16 healthy client-owned Bulldogs were enrolled. Methods: Retrospective case study. tMg concentrations were compared between Boxers and Bulldogs. Dogs with low serum albumin or high serum creatinine concentrations were excluded. Prospectively, ionized Mg (iMg), tMg, and arterial blood pressure were measured and iMg-to-tMg ratio (iMg: tMg) was calculated. Parenteral Mg tolerance testing (PMgTT) was performed in 3/16 dogs. Results: In the retrospective study, period prevalence of hypomagnesemia was 4.7% in Boxers and 15% in Bulldogs (P = .02). The risk ratio for hypomagnesemia in Bulldogs was 1.8 when compared to Boxers (CI: 1.3-2.7). In the prospective study, iMg was [median (interquartile)] 0.43 (0.42-0.46) mmol/L (reference range 0.4-0.52), tMg was 1.9 (1.8-1.9) mg/dL (reference range 1.9-2.5). iMg: tMg was [mean (±SD)] 0.59 ± 0.04. Percentage retention after PMgTT were 55%, 95%, and 67%, respectively. Conclusions and Clinical Importance: Mg deficiency is common in Bulldogs and could contribute to comorbidities often observed in this breed. iMg: tMg and PMgTT might prove helpful in detecting chronic subclinical Mg deficiency.

Original languageEnglish (US)
Pages (from-to)1418-1423
Number of pages6
JournalJournal of Veterinary Internal Medicine
Volume28
Issue number5
DOIs
StatePublished - Sep 1 2014

Fingerprint

hypomagnesemia
Magnesium
magnesium
Magnesium Deficiency
Boxer (dog breed)
Dogs
dogs
Reference Values
Retrospective Studies
Laboratory Animals
Obstructive Sleep Apnea
Serum
Serum Albumin
Teaching Hospitals
testing
sleep apnea
Comorbidity
Creatinine
Arterial Pressure
Referral and Consultation

Keywords

  • Boxer
  • Bulldog
  • Hypercapnea
  • Intracellular magnesium
  • Parenteral magnesium tolerance testing
  • Sleep apnea-hypopnea syndrome

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Hypomagnesemia in Brachycephalic Dogs. / Mellema, M. S.; Hoareau, G. L.

In: Journal of Veterinary Internal Medicine, Vol. 28, No. 5, 01.09.2014, p. 1418-1423.

Research output: Contribution to journalArticle

Mellema, M. S. ; Hoareau, G. L. / Hypomagnesemia in Brachycephalic Dogs. In: Journal of Veterinary Internal Medicine. 2014 ; Vol. 28, No. 5. pp. 1418-1423.
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