TY - JOUR
T1 - Hypocholesterolemia in cats
T2 - a multicenter retrospective study of 106 cats
AU - Bowman, Claudia
AU - Viall, Austin
AU - Rudinsky, Adam
AU - Gilor, Chen
AU - Palerme, Jean Sébastien
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Objectives: The aim of this study was to describe the clinicopathologic findings and associated diseases found in a population of hypocholesterolemic cats referred to two tertiary care facilities. Methods: An electronic medical record search was performed at two veterinary university referral centers to identify cats with serum cholesterol values below reference interval between January 2004 and 2016. Clinicopathologic data were reviewed for each case and cats were classified into specific disease categories based on clinical diagnosis. Median cholesterol values were compared between disease categories, as well as between survivors and non-survivors. Results: In total, 106 hypocholesterolemic cats were included. The median age of the cats was 6 years (range 0.24–18 years). The most common disease categories were gastrointestinal (25.9%), hepatobiliary (19.8%), hematologic (14.8%) and urogenital (14.8%). Though median serum cholesterol values did not differ significantly between survivors and non-survivors, cats with concurrent hypoalbuminemia were at higher risk (odds ratio 15.6, 95% confidence interval 5.2–46.6; P <0.0001) of not surviving to discharge than cats with normal serum albumin concentrations. Conclusions and relevance: Taken together, our data suggest that while the degree of hypocholesterolemia did not appear to influence survival rates, the concurrent presence of hypocholesterolemia and hypoalbuminemia was associated with a worse prognosis.
AB - Objectives: The aim of this study was to describe the clinicopathologic findings and associated diseases found in a population of hypocholesterolemic cats referred to two tertiary care facilities. Methods: An electronic medical record search was performed at two veterinary university referral centers to identify cats with serum cholesterol values below reference interval between January 2004 and 2016. Clinicopathologic data were reviewed for each case and cats were classified into specific disease categories based on clinical diagnosis. Median cholesterol values were compared between disease categories, as well as between survivors and non-survivors. Results: In total, 106 hypocholesterolemic cats were included. The median age of the cats was 6 years (range 0.24–18 years). The most common disease categories were gastrointestinal (25.9%), hepatobiliary (19.8%), hematologic (14.8%) and urogenital (14.8%). Though median serum cholesterol values did not differ significantly between survivors and non-survivors, cats with concurrent hypoalbuminemia were at higher risk (odds ratio 15.6, 95% confidence interval 5.2–46.6; P <0.0001) of not surviving to discharge than cats with normal serum albumin concentrations. Conclusions and relevance: Taken together, our data suggest that while the degree of hypocholesterolemia did not appear to influence survival rates, the concurrent presence of hypocholesterolemia and hypoalbuminemia was associated with a worse prognosis.
KW - cholesterol
KW - dyslipidemia
KW - hypoalbuminemia
KW - Hypocholesterolemia
KW - prognosis
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U2 - 10.1177/1098612X19886398
DO - 10.1177/1098612X19886398
M3 - Article
C2 - 31710272
AN - SCOPUS:85075024038
JO - Journal of Feline Medicine and Surgery
JF - Journal of Feline Medicine and Surgery
SN - 1098-612X
ER -