HYPOCHOLESTEROLAEMIA AND INCREASED ELIMINATION OF LOW-DENSITY LIPOPROTEINS IN METASTATIC CANCER OF THE PROSTATE

Peter Henriksson, Sverker Ericsson, Reinhard Stege, Mats Eriksson, Mats Rudling, Lars Berglund, Bo Angelin

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Abstract

To study the influence of tumour mass on lipid metabolism, the lipoprotein pattern in untreated patients with newly diagnosed cancer of the prostate was examined. Total cholesterol levels were reduced in patients with evidence of metastasis (n=30) compared with those without metastasis (n = 73). Since the major fraction of serum cholesterol is contained in low-density lipoproteins (LDL), turnover of LDL was studied in detail in 8 patients compared with 12 age-matched healthy men. LDL were cleared faster in the 3 patients with metastatic disease than in the patients without metastasis and in controls, indicating faster catabolism of LDL. Thus in prostatic cancer an increased tumour burden is associated with increased elimination of LDL, which contributes to reduced serum cholesterol levels.

Original languageEnglish (US)
Pages (from-to)1178-1180
Number of pages3
JournalThe Lancet
Volume334
Issue number8673
DOIs
StatePublished - Nov 18 1989
Externally publishedYes

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ASJC Scopus subject areas

  • Medicine(all)

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