Hyperventilation-induced panic attacks in panic disorder with agoraphobia

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Eight minutes of hyperventilation to an end-tidal PCO2 of less than 20 mmHg led to a panic attack in 7 of 12 patients with panic disorder with agoraphobia and only 1 of 12 normal controls. Patients experienced greater increases in panic symptoms than controls during hyperventilation. Patients who reported more distress from somatic symptoms of hyperventilation during the preceding week were more likely to panic during hyperventilation. Patients who panicked during hyperventilation exhibited a delayed recovery of normocapnia following hyperventilation. Hyperventilation by this protocol is an effective means of inducing panic attacks in the laboratory. A hyperventilation challenge may identify a subgroup of patients for whom hyperventilation symptoms are frequently associated with panic.

Original languageEnglish (US)
Pages (from-to)843-854
Number of pages12
JournalBiological Psychiatry
Volume29
Issue number9
DOIs
StatePublished - May 1 1991

Fingerprint

Agoraphobia
Hyperventilation
Panic Disorder
Panic

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Hyperventilation-induced panic attacks in panic disorder with agoraphobia. / Maddock, Richard J; Carter, Cameron S.

In: Biological Psychiatry, Vol. 29, No. 9, 01.05.1991, p. 843-854.

Research output: Contribution to journalArticle

@article{1a810f0adb04460ab89654bc231c7e58,
title = "Hyperventilation-induced panic attacks in panic disorder with agoraphobia",
abstract = "Eight minutes of hyperventilation to an end-tidal PCO2 of less than 20 mmHg led to a panic attack in 7 of 12 patients with panic disorder with agoraphobia and only 1 of 12 normal controls. Patients experienced greater increases in panic symptoms than controls during hyperventilation. Patients who reported more distress from somatic symptoms of hyperventilation during the preceding week were more likely to panic during hyperventilation. Patients who panicked during hyperventilation exhibited a delayed recovery of normocapnia following hyperventilation. Hyperventilation by this protocol is an effective means of inducing panic attacks in the laboratory. A hyperventilation challenge may identify a subgroup of patients for whom hyperventilation symptoms are frequently associated with panic.",
author = "Maddock, {Richard J} and Carter, {Cameron S}",
year = "1991",
month = "5",
day = "1",
doi = "10.1016/0006-3223(91)90051-M",
language = "English (US)",
volume = "29",
pages = "843--854",
journal = "Biological Psychiatry",
issn = "0006-3223",
publisher = "Elsevier USA",
number = "9",

}

TY - JOUR

T1 - Hyperventilation-induced panic attacks in panic disorder with agoraphobia

AU - Maddock, Richard J

AU - Carter, Cameron S

PY - 1991/5/1

Y1 - 1991/5/1

N2 - Eight minutes of hyperventilation to an end-tidal PCO2 of less than 20 mmHg led to a panic attack in 7 of 12 patients with panic disorder with agoraphobia and only 1 of 12 normal controls. Patients experienced greater increases in panic symptoms than controls during hyperventilation. Patients who reported more distress from somatic symptoms of hyperventilation during the preceding week were more likely to panic during hyperventilation. Patients who panicked during hyperventilation exhibited a delayed recovery of normocapnia following hyperventilation. Hyperventilation by this protocol is an effective means of inducing panic attacks in the laboratory. A hyperventilation challenge may identify a subgroup of patients for whom hyperventilation symptoms are frequently associated with panic.

AB - Eight minutes of hyperventilation to an end-tidal PCO2 of less than 20 mmHg led to a panic attack in 7 of 12 patients with panic disorder with agoraphobia and only 1 of 12 normal controls. Patients experienced greater increases in panic symptoms than controls during hyperventilation. Patients who reported more distress from somatic symptoms of hyperventilation during the preceding week were more likely to panic during hyperventilation. Patients who panicked during hyperventilation exhibited a delayed recovery of normocapnia following hyperventilation. Hyperventilation by this protocol is an effective means of inducing panic attacks in the laboratory. A hyperventilation challenge may identify a subgroup of patients for whom hyperventilation symptoms are frequently associated with panic.

UR - http://www.scopus.com/inward/record.url?scp=0025822304&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025822304&partnerID=8YFLogxK

U2 - 10.1016/0006-3223(91)90051-M

DO - 10.1016/0006-3223(91)90051-M

M3 - Article

VL - 29

SP - 843

EP - 854

JO - Biological Psychiatry

JF - Biological Psychiatry

SN - 0006-3223

IS - 9

ER -