Abstract
Hypertrophic cardiomyopathy is an inherited disease in some feline breeds including the Maine Coon and Ragdoll. In these breeds, distinct causative genetic mutations have been identified. The two breeds appear to have slightly different clinical presentations, including age of diagnosis. The observation that these two breeds may have different clinical presentations, as well as different genetic mutations, suggests that hypertrophic cardiomyopathy is a diverse disease in the cat. Hypertrophic cardiomyopathy is poorly described in the Sphynx. The objective of this study was to phenotypically characterize Sphynx hypertrophic cardiomyopathy and to evaluate for a familial etiology. Records of 18 affected cats (11 female, seven male) were evaluated. Age of affected cats ranged from 0.5 to 7 years (median, 2 years). Four affected cats were from a single family and included an affected cat in each of four generations (three females, one male). Further studies are warranted to evaluate for a causative mutation and better classify the phenotypic expression.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 246-249 |
| Number of pages | 4 |
| Journal | Journal of Feline Medicine and Surgery |
| Volume | 14 |
| Issue number | 4 |
| DOIs | |
| State | Published - 2013 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Small Animals
Cite this
Hypertrophic cardiomyopathy in the Sphynx cat : A retrospective evaluation of clinical presentation and heritable etiology. / Silverman, Sarah J.; Stern, Joshua A; Meurs, Kathryn M.
In: Journal of Feline Medicine and Surgery, Vol. 14, No. 4, 2013, p. 246-249.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Hypertrophic cardiomyopathy in the Sphynx cat
T2 - A retrospective evaluation of clinical presentation and heritable etiology
AU - Silverman, Sarah J.
AU - Stern, Joshua A
AU - Meurs, Kathryn M.
PY - 2013
Y1 - 2013
N2 - Hypertrophic cardiomyopathy is an inherited disease in some feline breeds including the Maine Coon and Ragdoll. In these breeds, distinct causative genetic mutations have been identified. The two breeds appear to have slightly different clinical presentations, including age of diagnosis. The observation that these two breeds may have different clinical presentations, as well as different genetic mutations, suggests that hypertrophic cardiomyopathy is a diverse disease in the cat. Hypertrophic cardiomyopathy is poorly described in the Sphynx. The objective of this study was to phenotypically characterize Sphynx hypertrophic cardiomyopathy and to evaluate for a familial etiology. Records of 18 affected cats (11 female, seven male) were evaluated. Age of affected cats ranged from 0.5 to 7 years (median, 2 years). Four affected cats were from a single family and included an affected cat in each of four generations (three females, one male). Further studies are warranted to evaluate for a causative mutation and better classify the phenotypic expression.
AB - Hypertrophic cardiomyopathy is an inherited disease in some feline breeds including the Maine Coon and Ragdoll. In these breeds, distinct causative genetic mutations have been identified. The two breeds appear to have slightly different clinical presentations, including age of diagnosis. The observation that these two breeds may have different clinical presentations, as well as different genetic mutations, suggests that hypertrophic cardiomyopathy is a diverse disease in the cat. Hypertrophic cardiomyopathy is poorly described in the Sphynx. The objective of this study was to phenotypically characterize Sphynx hypertrophic cardiomyopathy and to evaluate for a familial etiology. Records of 18 affected cats (11 female, seven male) were evaluated. Age of affected cats ranged from 0.5 to 7 years (median, 2 years). Four affected cats were from a single family and included an affected cat in each of four generations (three females, one male). Further studies are warranted to evaluate for a causative mutation and better classify the phenotypic expression.
UR - http://www.scopus.com/inward/record.url?scp=84864070337&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84864070337&partnerID=8YFLogxK
U2 - 10.1177/1098612X11435040
DO - 10.1177/1098612X11435040
M3 - Article
C2 - 22412161
AN - SCOPUS:84864070337
VL - 14
SP - 246
EP - 249
JO - Journal of Feline Medicine and Surgery
JF - Journal of Feline Medicine and Surgery
SN - 1098-612X
IS - 4
ER -