Hyperthyroidism in gestational trophoblastic neoplasia

R. J. Norman, R. W. Green-Thompson, I. Jialal, W. P. Soutter, N. L. Pillay, S. M. Joubert

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40 Scopus citations


The thyroid status of twenty-seven African patients wth gestational trophoblastic neoplasia (GTN) was studied. Fifteen patients were found to be biochemically hyperthyroid (eight patients with choriocarcinoma; seven with hydatidiform mole). Of these fifteen patients, nine were clinically thyrotoxic. The most serious complication of thyrotoxicosis was life-threatening acute pulmonary oedema with associated cardiac failure. It was found that when serum levels of the human chorionic gonadotrophin (hCG) reached a level of about 0.1 x 106 iu/l, thirteen of sixteen patients were biochemically hyperthyroid; at serum levels of 0.3 x 106 iu/l of hCG most patients were clinically thyrotoxic. A feature of hyperthyroidism associated with GTN is that whereas T4 is invariably raised the T3:T4 ratio tends to be low (0.015±0.005); rT3:T3 ratios were high in this group. TSH levels were not increased.

Original languageEnglish (US)
Pages (from-to)395-401
Number of pages7
JournalClinical Endocrinology
Issue number4
StatePublished - 1981
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology


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