Hyperthermia and halothane MAC in the dog

Eugene Steffey, E. I. Eger

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


To evaluate the effect of hyperthermia on anesthetic requirement, the changes in minimum alveolar concentration (MAC) of halothane which accompanied increases in esophageal temperatures from 37.3 to 45.9C were determined in 8 spontaneously breathing dogs. MAC increased linearly by 27% as temperature rose to 40.7C (i.e., 8% per degree C). At temperatures above 42C MAC decreased. Death occurred at a mean temperature of 45.9C.

Original languageEnglish (US)
Pages (from-to)392-396
Number of pages5
Issue number4
StatePublished - Dec 1 1974
Externally publishedYes

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine


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