Hyperreactio luteinalis in a monochorionic twin pregnancy complicated by preeclampsia: A case report

Laura Sienas, Trevor Miller, Juliana R Melo, Herman Hedriana

Research output: Contribution to journalArticlepeer-review


Hyperreactio luteinalis (HL) is a rare benign complication of pregnancy that is characterized by progressive ovarian enlargement and hyperandrogenism. We present a case of a 30-year-old woman with a spontaneous monochorionic diamniotic twin pregnancy who presented with early-onset preeclampsia, concern about possible twin-twin transfusion syndrome, and bilateral enlarged ovarian masses. Both ovaries had multiple thin-walled unilocular cysts; one ovary measured 17.9 × 17.5 × 9.1 cm and the other 12.5 × 11 × 12.3 cm. After extensive counseling, the patient underwent an uncomplicated dilation and evacuation. Postoperative assessment indicated elevated androgen levels, which spontaneously resolved, supporting the clinical diagnosis of HL. It is important to consider HL in the differential diagnosis of adnexal masses in pregnancy. HL spontaneously regresses after delivery and is managed expectantly. HL has been associated with gestational trophoblastic disease, multiple gestations, preeclampsia, and twin-twin transfusion syndrome.

Original languageEnglish (US)
Article numbere00073
JournalCase Reports in Women's Health
StatePublished - Jul 1 2018


  • Adnexal mass
  • Hyperandrogenism
  • Preeclampsia
  • Pregnancy
  • Twin-twin transfusion syndrome

ASJC Scopus subject areas

  • Obstetrics and Gynecology


Dive into the research topics of 'Hyperreactio luteinalis in a monochorionic twin pregnancy complicated by preeclampsia: A case report'. Together they form a unique fingerprint.

Cite this