Hyperplastic polyps of the colon and rectum. An immunohistochemical study with monoclonal antibodies against blood groups antigens (Sialosyl-Lea, Leb, Le(x), Le(y), A, B, H)

H. S. Cooper, Carol S Marshall, F. Ruggerio, Z. Steplewski

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Abstract

We studied 40 hyperplastic polyps (HP) immunohistochemically with monoclonal antibodies against 8 different blood group antigens (BGA) comparing their reactivity with normal control colon and colorectal adenocarcinomas. The 8 BGA studied were: Sialosyl-Lea, Lea, Leb, Le(x), Le(y), A, B, and H. Sialosyl-Lea, Lea, Le(x), and Le(y) can be thought of as differentiation antigens. The former 2 BGA are expressed on mature (differentiated) epithelium while the latter 2 BGA are expressed by undifferentiated epithelium of the crypt base. A, B, H and Leb are not expressed in the normal distal colon, however, they are extenively expressed on distal colorectal cancers and andenomas and can be considered onocofetal BGA. HP expressed Lea, Le(x), Le(y) in the same compartment of the crypt as normal colon and extensively expressed Sialosyl-Lea throughout the entire length of the crypt. This latter finding indicated maturation at a lower point in the crypt than in normals. All HP failed to express B and H BGA, while 6 of 40 expressed Leb and 5 of 50 HP expressed A BGA. Of the 6 HP expressing Leb BGA, 3 were from patients with synchronous or metachronous cancers and 2 from patients with mixed hyperplastic polyp-adenomas (HP/AD). Two of the HP expressing A BGA were from patients with HP/AD. The expression and distribution of these BGA in HP, especially the extensive expression of sialosyl-Lea correlates with the known cell kinetics of HP. While nonneoplastic in nature, HP may occasionally express true oncofetal BGA. Similarly, the HP component of HP/AD may also express true onocofetal BGA. These data suggest that the lesions classified morphologically as HP may be antigenically heterogenous.

Original languageEnglish (US)
Pages (from-to)421-428
Number of pages8
JournalLaboratory Investigation
Volume57
Issue number4
StatePublished - 1987
Externally publishedYes

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Blood Group Antigens
Polyps
Rectum
Colon
Monoclonal Antibodies
Epithelium
ABO Blood-Group System
Differentiation Antigens
Adenoma
Colorectal Neoplasms
Adenocarcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

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title = "Hyperplastic polyps of the colon and rectum. An immunohistochemical study with monoclonal antibodies against blood groups antigens (Sialosyl-Lea, Leb, Le(x), Le(y), A, B, H)",
abstract = "We studied 40 hyperplastic polyps (HP) immunohistochemically with monoclonal antibodies against 8 different blood group antigens (BGA) comparing their reactivity with normal control colon and colorectal adenocarcinomas. The 8 BGA studied were: Sialosyl-Lea, Lea, Leb, Le(x), Le(y), A, B, and H. Sialosyl-Lea, Lea, Le(x), and Le(y) can be thought of as differentiation antigens. The former 2 BGA are expressed on mature (differentiated) epithelium while the latter 2 BGA are expressed by undifferentiated epithelium of the crypt base. A, B, H and Leb are not expressed in the normal distal colon, however, they are extenively expressed on distal colorectal cancers and andenomas and can be considered onocofetal BGA. HP expressed Lea, Le(x), Le(y) in the same compartment of the crypt as normal colon and extensively expressed Sialosyl-Lea throughout the entire length of the crypt. This latter finding indicated maturation at a lower point in the crypt than in normals. All HP failed to express B and H BGA, while 6 of 40 expressed Leb and 5 of 50 HP expressed A BGA. Of the 6 HP expressing Leb BGA, 3 were from patients with synchronous or metachronous cancers and 2 from patients with mixed hyperplastic polyp-adenomas (HP/AD). Two of the HP expressing A BGA were from patients with HP/AD. The expression and distribution of these BGA in HP, especially the extensive expression of sialosyl-Lea correlates with the known cell kinetics of HP. While nonneoplastic in nature, HP may occasionally express true oncofetal BGA. Similarly, the HP component of HP/AD may also express true onocofetal BGA. These data suggest that the lesions classified morphologically as HP may be antigenically heterogenous.",
author = "Cooper, {H. S.} and Marshall, {Carol S} and F. Ruggerio and Z. Steplewski",
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T1 - Hyperplastic polyps of the colon and rectum. An immunohistochemical study with monoclonal antibodies against blood groups antigens (Sialosyl-Lea, Leb, Le(x), Le(y), A, B, H)

AU - Cooper, H. S.

AU - Marshall, Carol S

AU - Ruggerio, F.

AU - Steplewski, Z.

PY - 1987

Y1 - 1987

N2 - We studied 40 hyperplastic polyps (HP) immunohistochemically with monoclonal antibodies against 8 different blood group antigens (BGA) comparing their reactivity with normal control colon and colorectal adenocarcinomas. The 8 BGA studied were: Sialosyl-Lea, Lea, Leb, Le(x), Le(y), A, B, and H. Sialosyl-Lea, Lea, Le(x), and Le(y) can be thought of as differentiation antigens. The former 2 BGA are expressed on mature (differentiated) epithelium while the latter 2 BGA are expressed by undifferentiated epithelium of the crypt base. A, B, H and Leb are not expressed in the normal distal colon, however, they are extenively expressed on distal colorectal cancers and andenomas and can be considered onocofetal BGA. HP expressed Lea, Le(x), Le(y) in the same compartment of the crypt as normal colon and extensively expressed Sialosyl-Lea throughout the entire length of the crypt. This latter finding indicated maturation at a lower point in the crypt than in normals. All HP failed to express B and H BGA, while 6 of 40 expressed Leb and 5 of 50 HP expressed A BGA. Of the 6 HP expressing Leb BGA, 3 were from patients with synchronous or metachronous cancers and 2 from patients with mixed hyperplastic polyp-adenomas (HP/AD). Two of the HP expressing A BGA were from patients with HP/AD. The expression and distribution of these BGA in HP, especially the extensive expression of sialosyl-Lea correlates with the known cell kinetics of HP. While nonneoplastic in nature, HP may occasionally express true oncofetal BGA. Similarly, the HP component of HP/AD may also express true onocofetal BGA. These data suggest that the lesions classified morphologically as HP may be antigenically heterogenous.

AB - We studied 40 hyperplastic polyps (HP) immunohistochemically with monoclonal antibodies against 8 different blood group antigens (BGA) comparing their reactivity with normal control colon and colorectal adenocarcinomas. The 8 BGA studied were: Sialosyl-Lea, Lea, Leb, Le(x), Le(y), A, B, and H. Sialosyl-Lea, Lea, Le(x), and Le(y) can be thought of as differentiation antigens. The former 2 BGA are expressed on mature (differentiated) epithelium while the latter 2 BGA are expressed by undifferentiated epithelium of the crypt base. A, B, H and Leb are not expressed in the normal distal colon, however, they are extenively expressed on distal colorectal cancers and andenomas and can be considered onocofetal BGA. HP expressed Lea, Le(x), Le(y) in the same compartment of the crypt as normal colon and extensively expressed Sialosyl-Lea throughout the entire length of the crypt. This latter finding indicated maturation at a lower point in the crypt than in normals. All HP failed to express B and H BGA, while 6 of 40 expressed Leb and 5 of 50 HP expressed A BGA. Of the 6 HP expressing Leb BGA, 3 were from patients with synchronous or metachronous cancers and 2 from patients with mixed hyperplastic polyp-adenomas (HP/AD). Two of the HP expressing A BGA were from patients with HP/AD. The expression and distribution of these BGA in HP, especially the extensive expression of sialosyl-Lea correlates with the known cell kinetics of HP. While nonneoplastic in nature, HP may occasionally express true oncofetal BGA. Similarly, the HP component of HP/AD may also express true onocofetal BGA. These data suggest that the lesions classified morphologically as HP may be antigenically heterogenous.

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