Hyperoxia-induced airway hyperreactivity in neonatal guinea pigs is not inflammation dependent

Andrew T. Canada, Scott R. Schulman, Darrell W. Winsett, Kent E Pinkerton, Daniel Costa

Research output: Contribution to journalArticle

Abstract

A high percentage of neonatal human infants exposed to prolonged assisted ventilation with supplemental oxygen develop airway hyperreactivity. In order to demonstrate that this effect could be replicated in guinea pigs, 4-day-old pups were exposed either to air or 70% oxygen for 4 days. Nine days later each group was subjected to a histamine challenge and differences in respiratory mechanics were determined. The airway pressure response of the hyperoxia group was significantly greater and the respiratory compliance was significantly less than those of the air-exposed pups. The role of inflammation was assessed both by analysis of bronchoalveolar lavage fluid (BAL) and by histopathology on animals 1 day after discontinuation of the exposures. There were no differences between the two groups in BAL protein, total cell count, or the white blood cell (WBC) differential. Histology did not show any evidence of a difference between the two groups in inflammation or in airway remodeling.

Original languageEnglish (US)
Pages (from-to)15-25
Number of pages11
JournalInhalation Toxicology
Volume10
Issue number1
StatePublished - Jan 1998

Fingerprint

Hyperoxia
Bronchoalveolar Lavage Fluid
Guinea Pigs
Air
Oxygen
Inflammation
Respiratory Mechanics
Airway Remodeling
Respiratory mechanics
Leukocyte Count
Histamine
Compliance
Ventilation
Histology
Fluids
Cell Count
Pressure
Animals
Blood
Cells

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Hyperoxia-induced airway hyperreactivity in neonatal guinea pigs is not inflammation dependent. / Canada, Andrew T.; Schulman, Scott R.; Winsett, Darrell W.; Pinkerton, Kent E; Costa, Daniel.

In: Inhalation Toxicology, Vol. 10, No. 1, 01.1998, p. 15-25.

Research output: Contribution to journalArticle

Canada, AT, Schulman, SR, Winsett, DW, Pinkerton, KE & Costa, D 1998, 'Hyperoxia-induced airway hyperreactivity in neonatal guinea pigs is not inflammation dependent', Inhalation Toxicology, vol. 10, no. 1, pp. 15-25.
Canada, Andrew T. ; Schulman, Scott R. ; Winsett, Darrell W. ; Pinkerton, Kent E ; Costa, Daniel. / Hyperoxia-induced airway hyperreactivity in neonatal guinea pigs is not inflammation dependent. In: Inhalation Toxicology. 1998 ; Vol. 10, No. 1. pp. 15-25.
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