Hyperlocomotion induced by dopamine or cholecystokinin + dopamine in the nucleus accumbens is not modified by chronic lithium treatment

Joseph Zohar, Dennis L. Murphy, Jacqueline Crawley

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

1. 1. Peptides such as cholecystokinin have been reported to modulate the effects of dopaminergic agonists on locomotion in rats. 2. 2. The present experiments tested the possibility that lithium interacts with dopaminergic function through the same mechanism by which cholecystokinin potentiates dopaminergic function. 3. 3. The results suggest that dietary lithium has no effect on the ability of either dopamine alone, or the combination of dopamine plus cholecystokinin, microinjected directly into the nucleus accumbens, to stimulate hyperlocomotion.

Original languageEnglish (US)
Pages (from-to)775-779
Number of pages5
JournalProgress in Neuropsychopharmacology and Biological Psychiatry
Volume13
Issue number5
DOIs
StatePublished - 1989
Externally publishedYes

Keywords

  • cholecystokinin
  • dopamine
  • hyperlocomotion
  • lithium
  • nucleus accumbens

ASJC Scopus subject areas

  • Biological Psychiatry
  • Pharmacology

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