Hyperexcitability in the dentate gyrus of the epileptic Mongolian gerbil

Paul S. Buckmaster, Philip A Schwartzkroin

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

There are anatomical differences in the hippocampi of seizure-resistant (SR) vs. seizure-sensitive (SS) Mongolian gerbils. SS gerbils have more GABAergic neurons and more GABAergic axon terminals contacting inhibitory basket cells in the dentate gyrus. Hence, it has been hypothesized that inhibition of basket cells causes disinhibition of granule cells and results in hyperexcitability in SS gerbils. To test this hypothesis we measured the level of excitability in the dentate gyrus of anesthetized adult SS and SR gerbils, using a paired-pulse stimulus paradigm to evoke population spikes. Population spikes of SS and SR gerbils both showed strong paired-pulse inhibition at short interstimulus intervals and paired-pulse facilitation at intermediate interstimulus intervals. However, compared to SR gerbils, SS gerbils had significantly stronger paired-pulse facilitation which persisted at longer interstimulus intervals. These results show that SS gerbils have hyperexcitable dentate gyri and support the view that less effective inhibition is an underlying basis for this hyperexcitability.

Original languageEnglish (US)
Pages (from-to)23-28
Number of pages6
JournalEpilepsy Research
Volume18
Issue number1
DOIs
StatePublished - 1994
Externally publishedYes

Fingerprint

Gerbillinae
Dentate Gyrus
Seizures
GABAergic Neurons
Presynaptic Terminals
Population
Hippocampus

Keywords

  • Dentate gyrus
  • Gerbil
  • Hippocampus
  • Inhibition

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Neurology

Cite this

Hyperexcitability in the dentate gyrus of the epileptic Mongolian gerbil. / Buckmaster, Paul S.; Schwartzkroin, Philip A.

In: Epilepsy Research, Vol. 18, No. 1, 1994, p. 23-28.

Research output: Contribution to journalArticle

@article{63e97afbd9f24ae2b83fb498468d8859,
title = "Hyperexcitability in the dentate gyrus of the epileptic Mongolian gerbil",
abstract = "There are anatomical differences in the hippocampi of seizure-resistant (SR) vs. seizure-sensitive (SS) Mongolian gerbils. SS gerbils have more GABAergic neurons and more GABAergic axon terminals contacting inhibitory basket cells in the dentate gyrus. Hence, it has been hypothesized that inhibition of basket cells causes disinhibition of granule cells and results in hyperexcitability in SS gerbils. To test this hypothesis we measured the level of excitability in the dentate gyrus of anesthetized adult SS and SR gerbils, using a paired-pulse stimulus paradigm to evoke population spikes. Population spikes of SS and SR gerbils both showed strong paired-pulse inhibition at short interstimulus intervals and paired-pulse facilitation at intermediate interstimulus intervals. However, compared to SR gerbils, SS gerbils had significantly stronger paired-pulse facilitation which persisted at longer interstimulus intervals. These results show that SS gerbils have hyperexcitable dentate gyri and support the view that less effective inhibition is an underlying basis for this hyperexcitability.",
keywords = "Dentate gyrus, Gerbil, Hippocampus, Inhibition",
author = "Buckmaster, {Paul S.} and Schwartzkroin, {Philip A}",
year = "1994",
doi = "10.1016/0920-1211(94)90030-2",
language = "English (US)",
volume = "18",
pages = "23--28",
journal = "Epilepsy Research",
issn = "0920-1211",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - Hyperexcitability in the dentate gyrus of the epileptic Mongolian gerbil

AU - Buckmaster, Paul S.

AU - Schwartzkroin, Philip A

PY - 1994

Y1 - 1994

N2 - There are anatomical differences in the hippocampi of seizure-resistant (SR) vs. seizure-sensitive (SS) Mongolian gerbils. SS gerbils have more GABAergic neurons and more GABAergic axon terminals contacting inhibitory basket cells in the dentate gyrus. Hence, it has been hypothesized that inhibition of basket cells causes disinhibition of granule cells and results in hyperexcitability in SS gerbils. To test this hypothesis we measured the level of excitability in the dentate gyrus of anesthetized adult SS and SR gerbils, using a paired-pulse stimulus paradigm to evoke population spikes. Population spikes of SS and SR gerbils both showed strong paired-pulse inhibition at short interstimulus intervals and paired-pulse facilitation at intermediate interstimulus intervals. However, compared to SR gerbils, SS gerbils had significantly stronger paired-pulse facilitation which persisted at longer interstimulus intervals. These results show that SS gerbils have hyperexcitable dentate gyri and support the view that less effective inhibition is an underlying basis for this hyperexcitability.

AB - There are anatomical differences in the hippocampi of seizure-resistant (SR) vs. seizure-sensitive (SS) Mongolian gerbils. SS gerbils have more GABAergic neurons and more GABAergic axon terminals contacting inhibitory basket cells in the dentate gyrus. Hence, it has been hypothesized that inhibition of basket cells causes disinhibition of granule cells and results in hyperexcitability in SS gerbils. To test this hypothesis we measured the level of excitability in the dentate gyrus of anesthetized adult SS and SR gerbils, using a paired-pulse stimulus paradigm to evoke population spikes. Population spikes of SS and SR gerbils both showed strong paired-pulse inhibition at short interstimulus intervals and paired-pulse facilitation at intermediate interstimulus intervals. However, compared to SR gerbils, SS gerbils had significantly stronger paired-pulse facilitation which persisted at longer interstimulus intervals. These results show that SS gerbils have hyperexcitable dentate gyri and support the view that less effective inhibition is an underlying basis for this hyperexcitability.

KW - Dentate gyrus

KW - Gerbil

KW - Hippocampus

KW - Inhibition

UR - http://www.scopus.com/inward/record.url?scp=0028289827&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028289827&partnerID=8YFLogxK

U2 - 10.1016/0920-1211(94)90030-2

DO - 10.1016/0920-1211(94)90030-2

M3 - Article

C2 - 8088254

AN - SCOPUS:0028289827

VL - 18

SP - 23

EP - 28

JO - Epilepsy Research

JF - Epilepsy Research

SN - 0920-1211

IS - 1

ER -