Hyperamylinemia as a risk factor for accelerated cognitive decline in diabetes

Han Ly, Florin Despa

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Type II diabetes increases the risk for cognitive decline via multiple traits. Amylin is a pancreatic hormone that has amyloidogenic and cytotoxic properties similar to the amyloid-β peptide. The amylin hormone is overexpressed in individuals with pre-diabetic insulin resistance or obesity leading to amylin oligomerization and deposition in pancreatic islets. Amylin oligomerization was implicated in the apoptosis of the insulin-producing β-cells. Recent studies showed that brain tissue from diabetic patients with cerebrovascular dementia or Alzheimers disease contains significant deposits of oligomerized amylin. It has also been reported that the brain amylin deposition reduced exploratory drive, recognition memory and vestibulomotor function in a rat model that overexpresses human amylin in the pancreas. These novel findings are reviewed here and the hypothesis that type II diabetes is linked with cognitive decline by amylin accumulation in the brain is proposed. Deciphering the impact of hyperamylinemia on the brain is critical for both etiology and treatment of dementia.

Original languageEnglish (US)
Pages (from-to)575-577
Number of pages3
JournalExpert Review of Proteomics
Volume12
Issue number6
DOIs
StatePublished - Nov 2 2015
Externally publishedYes

Fingerprint

Islet Amyloid Polypeptide
Medical problems
Brain
Oligomerization
Type 2 Diabetes Mellitus
Dementia
Pancreatic Hormones
Insulin
Cerebrovascular Disorders
Cognitive Dysfunction
Islets of Langerhans
Amyloid
Insulin Resistance
Rats
Pancreas
Alzheimer Disease
Deposits
Obesity
Hormones
Tissue

Keywords

  • A?
  • Alzheimer's disease
  • amylin
  • amyloid
  • cerebrovascular disease
  • dementia
  • hyperamylinemia
  • hyperinsulinemia
  • insulin resistance
  • type 2 diabetes

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry

Cite this

Hyperamylinemia as a risk factor for accelerated cognitive decline in diabetes. / Ly, Han; Despa, Florin.

In: Expert Review of Proteomics, Vol. 12, No. 6, 02.11.2015, p. 575-577.

Research output: Contribution to journalArticle

Ly, Han ; Despa, Florin. / Hyperamylinemia as a risk factor for accelerated cognitive decline in diabetes. In: Expert Review of Proteomics. 2015 ; Vol. 12, No. 6. pp. 575-577.
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