TY - JOUR
T1 - Hyperammonemic encephalopathy
T2 - A rare presentation of fibrolamellar hepatocellular carcinoma
AU - Sethi, Saurabh
AU - Tageja, Nishant
AU - Singh, Jatinder
AU - Arabi, Haitham
AU - Dave, Maneesh
AU - Badheka, Apurva
AU - Revankar, Sanjay
PY - 2009/12
Y1 - 2009/12
N2 - Fibrolamellar carcinoma (FLC) is a rare malignant hepatocellular tumor of unknown etiology, arising almost exclusively from noninfected, noncirrhotic liver of young adults. FLC has traditionally been considered to have better survival than hepatocellular carcinoma; however, this notion might be highly erroneous. Patients with metastatic disease at presentation have a dismal prognosis with 5-year survival of only 15%. We describe a case of highly aggressive metastatic FLC that presented as hyperammonemic encephalopathy, which has never been previously reported in the literature.
AB - Fibrolamellar carcinoma (FLC) is a rare malignant hepatocellular tumor of unknown etiology, arising almost exclusively from noninfected, noncirrhotic liver of young adults. FLC has traditionally been considered to have better survival than hepatocellular carcinoma; however, this notion might be highly erroneous. Patients with metastatic disease at presentation have a dismal prognosis with 5-year survival of only 15%. We describe a case of highly aggressive metastatic FLC that presented as hyperammonemic encephalopathy, which has never been previously reported in the literature.
KW - Fibrolamellar carcinoma
KW - Hep Par 1
KW - Hyperammonemic encephalopathy
KW - Sorafenib
UR - http://www.scopus.com/inward/record.url?scp=73949145154&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=73949145154&partnerID=8YFLogxK
U2 - 10.1097/MAJ.0b013e3181bccfb4
DO - 10.1097/MAJ.0b013e3181bccfb4
M3 - Article
C2 - 20010160
AN - SCOPUS:73949145154
VL - 338
SP - 522
EP - 524
JO - American Journal of the Medical Sciences
JF - American Journal of the Medical Sciences
SN - 0002-9629
IS - 6
ER -