Hyperammonemic encephalopathy: A rare presentation of fibrolamellar hepatocellular carcinoma

Saurabh Sethi, Nishant Tageja, Jatinder Singh, Haitham Arabi, Maneesh Dave, Apurva Badheka, Sanjay Revankar

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Fibrolamellar carcinoma (FLC) is a rare malignant hepatocellular tumor of unknown etiology, arising almost exclusively from noninfected, noncirrhotic liver of young adults. FLC has traditionally been considered to have better survival than hepatocellular carcinoma; however, this notion might be highly erroneous. Patients with metastatic disease at presentation have a dismal prognosis with 5-year survival of only 15%. We describe a case of highly aggressive metastatic FLC that presented as hyperammonemic encephalopathy, which has never been previously reported in the literature.

Original languageEnglish (US)
Pages (from-to)522-524
Number of pages3
JournalAmerican Journal of the Medical Sciences
Volume338
Issue number6
DOIs
StatePublished - Dec 2009
Externally publishedYes

Keywords

  • Fibrolamellar carcinoma
  • Hep Par 1
  • Hyperammonemic encephalopathy
  • Sorafenib

ASJC Scopus subject areas

  • Medicine(all)

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