Hyperalgesia and increased neuropathic pain-like response in mice lacking galanin receptor 1 receptors

K. H. Blakeman, J. X. Hao, X. J. Xu, A. S. Jacoby, J. Shine, Jacqueline Crawley, T. Iismaa, Z. Wiesenfeld-Hallin

Research output: Contribution to journalArticlepeer-review

71 Scopus citations


The neuropeptide galanin may have a role in modulation of nociception, particularly after peripheral nerve injury. The effect of galanin is mediated by at least three subtypes of receptors. In the present study, we assessed the nociceptive sensitivity in mice lacking the galanin receptor 1 gene (Galr1) and the development of neuropathic pain-like behaviours after photochemically induced partial sciatic nerve ischaemic injury. Under basal condition, Galr1 knock-out (Galr1-/-) mice had shortened response latency on the hot plate, but not tail flick and paw radiant heat, tests. The mechanical sensitivity was not different between Galr1-/- and wild type (Galr1+/+) mice, whereas the cold response was moderately enhanced in Galr1-/- mice. Both Galr1-/- mice and Galr1+/+ controls developed mechanical and heat hypersensitivity after partial sciatic nerve injury. The duration of such pain-like behaviours was significantly increased in Galr1-/-. The Galr1-/- mice and Galr1+/+ mice did not differ in their recovery from deficits in toe-spread after sciatic nerve crush. The results provide some evidence for an inhibitory function for the neuropeptide galanin acting on galanin receptor 1 (GALR1) in nociception and neuropathic pain after peripheral nerve injury in mice.

Original languageEnglish (US)
Pages (from-to)221-227
Number of pages7
Issue number1
StatePublished - Mar 17 2003
Externally publishedYes


  • Antinociception
  • Neuropathy
  • Pain
  • Spinal cord

ASJC Scopus subject areas

  • Neuroscience(all)


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