Hydrosalpinx as a consequence of chlamydial salpingitis in the guinea pig

Guinea pig inclusion conjunctivitis (GPIC) is a naturally occurring C. psittaci infection which holds some promise as a model for human chlamydial infections. Both GPIC and C. trachomatis infections involve mucous membranes, appear to be restricted to squamocolumnar cells, infect the eye and the genital tract and can be transmitted to the newborn. In a previous publication we reported that direct inoculation of the GPIC agent into the fallopian tubes of guinea pigs resulted in an acute self-limited salpingitis. We report that some of these animals will go on to develop hydrosalpinx as a late consequence of the acute infection.