Hydration of cis- and trans-epoxymethyl stearates by the cytosolic epoxide hydrase of mouse liver

Sarjeet S. Gill, Bruce D. Hammock

Research output: Contribution to journalArticle

68 Scopus citations

Abstract

Man is exposed to epoxides of fatty acids from a number of sources, yet their degradative metabolism is not well understood. In mouse liver the 100,000 g supernatant or the cytosolic fraction is the most active fraction in hydrating cis- and trans-epoxymethyl stearates with the oxirane ring opening in a trans manner to give the corresponding threo and erythro diols, respectively. Hydration was also observed in the microsomal, nuclei and cell debris, and mitochondrial fractions in decreasing order of specific activity.

Original languageEnglish (US)
Pages (from-to)965-971
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume89
Issue number3
DOIs
StatePublished - Aug 13 1979

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ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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