Hybridization

S. M. Barcia, Kuang-Yu Jen

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Hybridization of nucleic acids is a reversible process by which single-stranded nucleic acids are allowed to interact in a sequence-specific manner to form complexes or hybrids. Assays which are based on nucleic acid hybridization are widely utilized in the research and clinical laboratory settings in order to detect and/or quantify specific nucleic acid sequences within samples or specimens.

Original languageEnglish (US)
Title of host publicationBrenner's Encyclopedia of Genetics
Subtitle of host publicationSecond Edition
PublisherElsevier Inc.
Pages593
Number of pages1
ISBN (Electronic)9780080961569
ISBN (Print)9780123749840
DOIs
StatePublished - Feb 27 2013
Externally publishedYes

Keywords

  • Complementary base pairing
  • FISH
  • Hybrid capture
  • Nucleic acids
  • Probe
  • Sequence specificity
  • Target

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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  • Cite this

    Barcia, S. M., & Jen, K-Y. (2013). Hybridization. In Brenner's Encyclopedia of Genetics: Second Edition (pp. 593). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-374984-0.00758-0