Abstract
Hybrid phospholipid/block copolymer vesicles, in which the polymeric membrane is blended with phospholipids, display interesting self-assembly behavior, incorporating the robustness and chemical versatility of polymersomes with the softness and biocompatibility of liposomes. Such structures can be conveniently characterized by preparing giant unilamellar vesicles (GUVs) via electroformation. Here, we are interested in exploring the self-assembly and properties of the analogous nanoscale hybrid vesicles (ca. 100 nm in diameter) of the same composition prepared by film-hydration and extrusion. We show that the self-assembly and content-release behavior of nanoscale polybutadieneb- poly(ethylene oxide) (PB-PEO)/1-palmitoyl-2-oleoyl-sn-glycero-3-phosphatidylcholine (POPC) hybrid phospholipid/block copolymer vesicles can be tuned by the mixing ratio of the amphiphiles. In brief, these hybrids may provide alternative tools for drug delivery purposes and molecular imaging/sensing applications and clearly open up new avenues for further investigation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1102-1114 |
| Number of pages | 13 |
| Journal | Polymers |
| Volume | 5 |
| Issue number | 3 |
| DOIs | |
| State | Published - 2013 |
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Keywords
- Drug-delivery
- Hybrid vesicles
- Polymersomes
- Self-assembly
- Soft matter
ASJC Scopus subject areas
- Polymers and Plastics
- Chemistry(all)
Cite this
Hybrid, nanoscale phospholipid/block copolymer vesicles. / Lim, Seng Koon; de Hoog, Hans Peter; Parikh, Atul N.; Nallani, Madhavan; Liedberg, Bo.
In: Polymers, Vol. 5, No. 3, 2013, p. 1102-1114.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Hybrid, nanoscale phospholipid/block copolymer vesicles
AU - Lim, Seng Koon
AU - de Hoog, Hans Peter
AU - Parikh, Atul N.
AU - Nallani, Madhavan
AU - Liedberg, Bo
PY - 2013
Y1 - 2013
N2 - Hybrid phospholipid/block copolymer vesicles, in which the polymeric membrane is blended with phospholipids, display interesting self-assembly behavior, incorporating the robustness and chemical versatility of polymersomes with the softness and biocompatibility of liposomes. Such structures can be conveniently characterized by preparing giant unilamellar vesicles (GUVs) via electroformation. Here, we are interested in exploring the self-assembly and properties of the analogous nanoscale hybrid vesicles (ca. 100 nm in diameter) of the same composition prepared by film-hydration and extrusion. We show that the self-assembly and content-release behavior of nanoscale polybutadieneb- poly(ethylene oxide) (PB-PEO)/1-palmitoyl-2-oleoyl-sn-glycero-3-phosphatidylcholine (POPC) hybrid phospholipid/block copolymer vesicles can be tuned by the mixing ratio of the amphiphiles. In brief, these hybrids may provide alternative tools for drug delivery purposes and molecular imaging/sensing applications and clearly open up new avenues for further investigation.
AB - Hybrid phospholipid/block copolymer vesicles, in which the polymeric membrane is blended with phospholipids, display interesting self-assembly behavior, incorporating the robustness and chemical versatility of polymersomes with the softness and biocompatibility of liposomes. Such structures can be conveniently characterized by preparing giant unilamellar vesicles (GUVs) via electroformation. Here, we are interested in exploring the self-assembly and properties of the analogous nanoscale hybrid vesicles (ca. 100 nm in diameter) of the same composition prepared by film-hydration and extrusion. We show that the self-assembly and content-release behavior of nanoscale polybutadieneb- poly(ethylene oxide) (PB-PEO)/1-palmitoyl-2-oleoyl-sn-glycero-3-phosphatidylcholine (POPC) hybrid phospholipid/block copolymer vesicles can be tuned by the mixing ratio of the amphiphiles. In brief, these hybrids may provide alternative tools for drug delivery purposes and molecular imaging/sensing applications and clearly open up new avenues for further investigation.
KW - Drug-delivery
KW - Hybrid vesicles
KW - Polymersomes
KW - Self-assembly
KW - Soft matter
UR - http://www.scopus.com/inward/record.url?scp=84885111051&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84885111051&partnerID=8YFLogxK
U2 - 10.3390/polym5031102
DO - 10.3390/polym5031102
M3 - Article
AN - SCOPUS:84885111051
VL - 5
SP - 1102
EP - 1114
JO - Polymers
JF - Polymers
SN - 2073-4360
IS - 3
ER -