Hybrid, nanoscale phospholipid/block copolymer vesicles

Seng Koon Lim, Hans Peter de Hoog, Atul N. Parikh, Madhavan Nallani, Bo Liedberg

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

Hybrid phospholipid/block copolymer vesicles, in which the polymeric membrane is blended with phospholipids, display interesting self-assembly behavior, incorporating the robustness and chemical versatility of polymersomes with the softness and biocompatibility of liposomes. Such structures can be conveniently characterized by preparing giant unilamellar vesicles (GUVs) via electroformation. Here, we are interested in exploring the self-assembly and properties of the analogous nanoscale hybrid vesicles (ca. 100 nm in diameter) of the same composition prepared by film-hydration and extrusion. We show that the self-assembly and content-release behavior of nanoscale polybutadieneb- poly(ethylene oxide) (PB-PEO)/1-palmitoyl-2-oleoyl-sn-glycero-3-phosphatidylcholine (POPC) hybrid phospholipid/block copolymer vesicles can be tuned by the mixing ratio of the amphiphiles. In brief, these hybrids may provide alternative tools for drug delivery purposes and molecular imaging/sensing applications and clearly open up new avenues for further investigation.

Original languageEnglish (US)
Pages (from-to)1102-1114
Number of pages13
JournalPolymers
Volume5
Issue number3
DOIs
StatePublished - 2013

Keywords

  • Drug-delivery
  • Hybrid vesicles
  • Polymersomes
  • Self-assembly
  • Soft matter

ASJC Scopus subject areas

  • Polymers and Plastics
  • Chemistry(all)

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  • Cite this

    Lim, S. K., de Hoog, H. P., Parikh, A. N., Nallani, M., & Liedberg, B. (2013). Hybrid, nanoscale phospholipid/block copolymer vesicles. Polymers, 5(3), 1102-1114. https://doi.org/10.3390/polym5031102