Abstract
Cumulative evidence from histology-based studies demonstrate that the currently available intravascular imaging techniques have fundamental limitations that do not allow complete and detailed evaluation of plaque morphology and pathobiology, limiting the ability to accurately identify high-risk plaques. To overcome these drawbacks, newefforts are developing for data fusion methodologies and the design of hybrid, dual-probe catheters to enable accurate assessment of plaque characteristics, and reliable identification of high-risk lesions. Today several dual-probe catheters have been introduced including combined near infrared spectroscopy-intravascular ultrasound (NIRS-IVUS), that is already commercially available, IVUS-optical coherence tomography (OCT), the OCT-NIRS, the OCT-near infrared fluorescence (NIRF) molecular imaging, IVUS-NIRF, IVUS intravascular photoacoustic imaging and combined fluorescence lifetime-IVUS imaging. These multimodal approaches appear able to overcome limitations of standalone imaging and provide comprehensive visualization of plaque composition and plaque biology. The aim of this review article is to summarize the advances in hybrid intravascular imaging, discuss the technical challenges that should be addressed in order to have a use in the clinical arena, and present the evidence from their first applications aiming to highlight their potential value in the study of atherosclerosis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 400-412b |
| Journal | European Heart Journal |
| Volume | 38 |
| Issue number | 6 |
| DOIs | |
| State | Published - Feb 1 2017 |
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Keywords
- Coronary atherosclerosis
- Hybrid imaging
- Intravascular imaging
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Hybrid intravascular imaging : Recent advances, technical considerations, and current applications in the study of plaque pathophysiology. / Bourantas, Christos V.; Jaffer, Farouc A.; Gijsen, Frank J.; Van Soest, Gijs; Madden, Sean P.; Courtney, Brian K.; Fard, Ali M.; Tenekecioglu, Erhan; Zeng, Yaping; Van Der Steen, Antonius F W; Emelianov, Stanislav; Muller, James; Stone, Peter H.; Marcu, Laura; Tearney, Guillermo J.; Serruys, Patrick W.
In: European Heart Journal, Vol. 38, No. 6, 01.02.2017, p. 400-412b.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Hybrid intravascular imaging
T2 - Recent advances, technical considerations, and current applications in the study of plaque pathophysiology
AU - Bourantas, Christos V.
AU - Jaffer, Farouc A.
AU - Gijsen, Frank J.
AU - Van Soest, Gijs
AU - Madden, Sean P.
AU - Courtney, Brian K.
AU - Fard, Ali M.
AU - Tenekecioglu, Erhan
AU - Zeng, Yaping
AU - Van Der Steen, Antonius F W
AU - Emelianov, Stanislav
AU - Muller, James
AU - Stone, Peter H.
AU - Marcu, Laura
AU - Tearney, Guillermo J.
AU - Serruys, Patrick W.
PY - 2017/2/1
Y1 - 2017/2/1
N2 - Cumulative evidence from histology-based studies demonstrate that the currently available intravascular imaging techniques have fundamental limitations that do not allow complete and detailed evaluation of plaque morphology and pathobiology, limiting the ability to accurately identify high-risk plaques. To overcome these drawbacks, newefforts are developing for data fusion methodologies and the design of hybrid, dual-probe catheters to enable accurate assessment of plaque characteristics, and reliable identification of high-risk lesions. Today several dual-probe catheters have been introduced including combined near infrared spectroscopy-intravascular ultrasound (NIRS-IVUS), that is already commercially available, IVUS-optical coherence tomography (OCT), the OCT-NIRS, the OCT-near infrared fluorescence (NIRF) molecular imaging, IVUS-NIRF, IVUS intravascular photoacoustic imaging and combined fluorescence lifetime-IVUS imaging. These multimodal approaches appear able to overcome limitations of standalone imaging and provide comprehensive visualization of plaque composition and plaque biology. The aim of this review article is to summarize the advances in hybrid intravascular imaging, discuss the technical challenges that should be addressed in order to have a use in the clinical arena, and present the evidence from their first applications aiming to highlight their potential value in the study of atherosclerosis.
AB - Cumulative evidence from histology-based studies demonstrate that the currently available intravascular imaging techniques have fundamental limitations that do not allow complete and detailed evaluation of plaque morphology and pathobiology, limiting the ability to accurately identify high-risk plaques. To overcome these drawbacks, newefforts are developing for data fusion methodologies and the design of hybrid, dual-probe catheters to enable accurate assessment of plaque characteristics, and reliable identification of high-risk lesions. Today several dual-probe catheters have been introduced including combined near infrared spectroscopy-intravascular ultrasound (NIRS-IVUS), that is already commercially available, IVUS-optical coherence tomography (OCT), the OCT-NIRS, the OCT-near infrared fluorescence (NIRF) molecular imaging, IVUS-NIRF, IVUS intravascular photoacoustic imaging and combined fluorescence lifetime-IVUS imaging. These multimodal approaches appear able to overcome limitations of standalone imaging and provide comprehensive visualization of plaque composition and plaque biology. The aim of this review article is to summarize the advances in hybrid intravascular imaging, discuss the technical challenges that should be addressed in order to have a use in the clinical arena, and present the evidence from their first applications aiming to highlight their potential value in the study of atherosclerosis.
KW - Coronary atherosclerosis
KW - Hybrid imaging
KW - Intravascular imaging
UR - http://www.scopus.com/inward/record.url?scp=85016193685&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85016193685&partnerID=8YFLogxK
U2 - 10.1093/eurheartj/ehw097
DO - 10.1093/eurheartj/ehw097
M3 - Review article
C2 - 27118197
AN - SCOPUS:85016193685
VL - 38
SP - 400-412b
JO - European Heart Journal
JF - European Heart Journal
SN - 0195-668X
IS - 6
ER -