Hybrid integration of injector and detector functions for microchip gas chromatography

Abhinav Bhushan, Dawit Yemane, Scott McDaniel, Jost Goettert, Michael C. Murphy, Edward B. Overton

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Hybrid microchips containing high aspect ratio gas chromatograph (GC) columns with an integrated on-chip split injection and a flame ionization detector were developed. Two different column configurations, spiral and serpentine, both 1 m long by 50 μm wide and 500 μm tall, were fabricated out of electrodeposited nickel. The hybrid chip allowed injection plugs on the order of 1-2 ms, which lowered the height equivalent to theoretical plates (HETP) and allowed a comparison of system level band broadening between the two column configurations. The gas phase band broadening was estimated by measuring the flow characteristics and peak broadening of an unretained compound, and the results were compared with kinetic models. Experimental results show that both spiral and serpentine column layouts had similar flow and band broadening, suggesting that gas phase band broadening may be independent of column layout. The necessity for narrow injection bands for fast micro-chip chromatographic analysis was demonstrated, which emphasized the importance of component integration in designing powerful micro-analytical systems.

Original languageEnglish (US)
Pages (from-to)2730-2736
Number of pages7
JournalAnalyst
Volume135
Issue number10
DOIs
StatePublished - Oct 2010

ASJC Scopus subject areas

  • Analytical Chemistry
  • Spectroscopy
  • Electrochemistry
  • Biochemistry
  • Environmental Chemistry

Fingerprint Dive into the research topics of 'Hybrid integration of injector and detector functions for microchip gas chromatography'. Together they form a unique fingerprint.

Cite this