Humoral immunity reflects altered T helper cell bias in Borrelia burgdorferi-infected γδ T-cell-deficient mice

Linda K. Bockenstedt, Marie Claude Shanafelt, Alexia Belperron, Jialing Mao, Stephen W Barthold

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

In murine Lyme borreliosis, the absence of γδ T lymphocytes augments the T helper cell 2 type humoral response but does not alter disease susceptibility. Arthropod transmission of Borrelia burgdorferi spirochetes results in similar antibody isotypes when γδ T cells are present, suggesting that vector effects can negate γδ T-cell functions in vivo.

Original languageEnglish (US)
Pages (from-to)2938-2940
Number of pages3
JournalInfection and Immunity
Volume71
Issue number5
DOIs
StatePublished - May 1 2003

ASJC Scopus subject areas

  • Immunology

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