Humoral immunity reflects altered T helper cell bias in Borrelia burgdorferi-infected γδ T-cell-deficient mice

Linda K. Bockenstedt, Marie Claude Shanafelt, Alexia Belperron, Jialing Mao, Stephen W Barthold

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

In murine Lyme borreliosis, the absence of γδ T lymphocytes augments the T helper cell 2 type humoral response but does not alter disease susceptibility. Arthropod transmission of Borrelia burgdorferi spirochetes results in similar antibody isotypes when γδ T cells are present, suggesting that vector effects can negate γδ T-cell functions in vivo.

Original languageEnglish (US)
Pages (from-to)2938-2940
Number of pages3
JournalInfection and Immunity
Volume71
Issue number5
DOIs
StatePublished - May 1 2003

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Borrelia burgdorferi
Humoral Immunity
Helper-Inducer T-Lymphocytes
T-Lymphocytes
Spirochaetales
Th2 Cells
Lyme Disease
Arthropods
Disease Susceptibility
Antibodies

ASJC Scopus subject areas

  • Immunology

Cite this

Humoral immunity reflects altered T helper cell bias in Borrelia burgdorferi-infected γδ T-cell-deficient mice. / Bockenstedt, Linda K.; Shanafelt, Marie Claude; Belperron, Alexia; Mao, Jialing; Barthold, Stephen W.

In: Infection and Immunity, Vol. 71, No. 5, 01.05.2003, p. 2938-2940.

Research output: Contribution to journalArticle

Bockenstedt, Linda K. ; Shanafelt, Marie Claude ; Belperron, Alexia ; Mao, Jialing ; Barthold, Stephen W. / Humoral immunity reflects altered T helper cell bias in Borrelia burgdorferi-infected γδ T-cell-deficient mice. In: Infection and Immunity. 2003 ; Vol. 71, No. 5. pp. 2938-2940.
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