Humoral immune response of calves to bluetongue virus infection.

Nigel J Maclachlan, H. W. Heidner, F. J. Fuller

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Humoral immune responses of 7 calves to bluetongue virus (BTV) infection were evaluated by plaque-reduction assay and immunoblotting. Most readily interpretable results were obtained with the immunoblot assay when colostrum-deprived calves were used, and sera were reacted with proteins in partially purified extracts of BTV. Viremia persisted in calves for 35 to 56 days, and BTV coexisted in blood for several weeks with virus-specific neutralizing antibody. Calves developed antibody to virus protein 2, the major determinant of virus neutralization, at 14 to 28 days after inoculation; this time interval also coincided with the appearance of neutralizing antibody in serum. Virus clearance in BTV-infected calves did not coincide with humoral immune responses to protein 2 or other virion proteins.

Original languageEnglish (US)
Pages (from-to)1031-1035
Number of pages5
JournalAmerican Journal of Veterinary Research
Issue number7
StatePublished - Jul 1987
Externally publishedYes

ASJC Scopus subject areas

  • veterinary(all)


Dive into the research topics of 'Humoral immune response of calves to bluetongue virus infection.'. Together they form a unique fingerprint.

Cite this