Abstract
Humoral mechanisms have been suspected in the pathophysiology of pulmonary embolism. In this study the individual influence of α adrenergic, β adrenergic and serotonin blockade on the lethal dose of pulmonary emboli made of autologous blood clot in awake dogs was determined. The mean lethal dose of pulmonary emboli (cc clot/kg) and the standard deviation for each treatment group were as follows: untreated 1.98±0.63; methysergide treated 2.83±1.38 (P<0.05); phenoxybenzamine pretreated 2.01±0.47 (P>0.9); propranolol pretreated 2.35±0.74 (P>0.3). During embolization, all animals developed progressive tachycardia, tachypnea, dyspnea, systemic venous hypertension and systemic arterial hypotension. Systemic arterial hypotension was significantly (P<0.05) less severe in methysergide pretreated dogs than in untreated dogs. There were no significant differences between pretreated and control dogs.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 209-211 |
| Number of pages | 3 |
| Journal | Surgical Forum |
| Volume | Vol.22 |
| State | Published - 1971 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Surgery
Cite this
Humoral blockade on lethal pulmonary embolism in the awake dog. / Jacobsen, D. C.; Soden, K. J.; Allen, P. D.; Daicoff, G. R.
In: Surgical Forum, Vol. Vol.22, 1971, p. 209-211.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Humoral blockade on lethal pulmonary embolism in the awake dog
AU - Jacobsen, D. C.
AU - Soden, K. J.
AU - Allen, P. D.
AU - Daicoff, G. R.
PY - 1971
Y1 - 1971
N2 - Humoral mechanisms have been suspected in the pathophysiology of pulmonary embolism. In this study the individual influence of α adrenergic, β adrenergic and serotonin blockade on the lethal dose of pulmonary emboli made of autologous blood clot in awake dogs was determined. The mean lethal dose of pulmonary emboli (cc clot/kg) and the standard deviation for each treatment group were as follows: untreated 1.98±0.63; methysergide treated 2.83±1.38 (P<0.05); phenoxybenzamine pretreated 2.01±0.47 (P>0.9); propranolol pretreated 2.35±0.74 (P>0.3). During embolization, all animals developed progressive tachycardia, tachypnea, dyspnea, systemic venous hypertension and systemic arterial hypotension. Systemic arterial hypotension was significantly (P<0.05) less severe in methysergide pretreated dogs than in untreated dogs. There were no significant differences between pretreated and control dogs.
AB - Humoral mechanisms have been suspected in the pathophysiology of pulmonary embolism. In this study the individual influence of α adrenergic, β adrenergic and serotonin blockade on the lethal dose of pulmonary emboli made of autologous blood clot in awake dogs was determined. The mean lethal dose of pulmonary emboli (cc clot/kg) and the standard deviation for each treatment group were as follows: untreated 1.98±0.63; methysergide treated 2.83±1.38 (P<0.05); phenoxybenzamine pretreated 2.01±0.47 (P>0.9); propranolol pretreated 2.35±0.74 (P>0.3). During embolization, all animals developed progressive tachycardia, tachypnea, dyspnea, systemic venous hypertension and systemic arterial hypotension. Systemic arterial hypotension was significantly (P<0.05) less severe in methysergide pretreated dogs than in untreated dogs. There were no significant differences between pretreated and control dogs.
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UR - http://www.scopus.com/inward/citedby.url?scp=0015161911&partnerID=8YFLogxK
M3 - Article
C2 - 4399269
AN - SCOPUS:0015161911
VL - Vol.22
SP - 209
EP - 211
JO - Surgical Forum
JF - Surgical Forum
SN - 0071-8041
ER -