Humoral blockade on lethal pulmonary embolism in the awake dog

D. C. Jacobsen, K. J. Soden, P. D. Allen, G. R. Daicoff

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Humoral mechanisms have been suspected in the pathophysiology of pulmonary embolism. In this study the individual influence of α adrenergic, β adrenergic and serotonin blockade on the lethal dose of pulmonary emboli made of autologous blood clot in awake dogs was determined. The mean lethal dose of pulmonary emboli (cc clot/kg) and the standard deviation for each treatment group were as follows: untreated 1.98±0.63; methysergide treated 2.83±1.38 (P<0.05); phenoxybenzamine pretreated 2.01±0.47 (P>0.9); propranolol pretreated 2.35±0.74 (P>0.3). During embolization, all animals developed progressive tachycardia, tachypnea, dyspnea, systemic venous hypertension and systemic arterial hypotension. Systemic arterial hypotension was significantly (P<0.05) less severe in methysergide pretreated dogs than in untreated dogs. There were no significant differences between pretreated and control dogs.

Original languageEnglish (US)
Pages (from-to)209-211
Number of pages3
JournalSurgical Forum
VolumeVol.22
StatePublished - 1971
Externally publishedYes

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Pulmonary Embolism
Dogs
Methysergide
Embolism
Adrenergic Agents
Hypotension
Tachypnea
Lung
Tachycardia
Propranolol
Dyspnea
Serotonin
Thrombosis
Hypertension

ASJC Scopus subject areas

  • Surgery

Cite this

Jacobsen, D. C., Soden, K. J., Allen, P. D., & Daicoff, G. R. (1971). Humoral blockade on lethal pulmonary embolism in the awake dog. Surgical Forum, Vol.22, 209-211.

Humoral blockade on lethal pulmonary embolism in the awake dog. / Jacobsen, D. C.; Soden, K. J.; Allen, P. D.; Daicoff, G. R.

In: Surgical Forum, Vol. Vol.22, 1971, p. 209-211.

Research output: Contribution to journalArticle

Jacobsen, DC, Soden, KJ, Allen, PD & Daicoff, GR 1971, 'Humoral blockade on lethal pulmonary embolism in the awake dog', Surgical Forum, vol. Vol.22, pp. 209-211.
Jacobsen DC, Soden KJ, Allen PD, Daicoff GR. Humoral blockade on lethal pulmonary embolism in the awake dog. Surgical Forum. 1971;Vol.22:209-211.
Jacobsen, D. C. ; Soden, K. J. ; Allen, P. D. ; Daicoff, G. R. / Humoral blockade on lethal pulmonary embolism in the awake dog. In: Surgical Forum. 1971 ; Vol. Vol.22. pp. 209-211.
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