Abstract
Humoral mechanisms have been suspected in the pathophysiology of pulmonary embolism. In this study the individual influence of α adrenergic, β adrenergic and serotonin blockade on the lethal dose of pulmonary emboli made of autologous blood clot in awake dogs was determined. The mean lethal dose of pulmonary emboli (cc clot/kg) and the standard deviation for each treatment group were as follows: untreated 1.98±0.63; methysergide treated 2.83±1.38 (P<0.05); phenoxybenzamine pretreated 2.01±0.47 (P>0.9); propranolol pretreated 2.35±0.74 (P>0.3). During embolization, all animals developed progressive tachycardia, tachypnea, dyspnea, systemic venous hypertension and systemic arterial hypotension. Systemic arterial hypotension was significantly (P<0.05) less severe in methysergide pretreated dogs than in untreated dogs. There were no significant differences between pretreated and control dogs.
Original language | English (US) |
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Pages (from-to) | 209-211 |
Number of pages | 3 |
Journal | Surgical Forum |
Volume | Vol.22 |
State | Published - 1971 |
Externally published | Yes |
ASJC Scopus subject areas
- Surgery