Human peripheral nerve sheath neoplasm: Expression of Schwann cell-related markers and their relation to malignant transformation

T. Yasuda, G. Sobue, Takayuki Ito, M. Doyu, I. Sugiura, Y. Hashizume, K. Kato

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

We immunohistochemically examined the expression of Schwann cell-related markers, nerve growth factor (NGF) receptor, S-100 α- and β-proteins, glial fibrillary acidic protein (GFAP), and galactocerebroside (gal C) in 5 malignant schwannomas, 21 benign peripheral nerve sheath tumors, and 4 apparently normal sural nerves. NGF receptor was expressed in the malignant schwannomas and benign peripheral nerve sheath tumors, but not in the endoneurium of apparently normal peripheral nerves. S-100 α-protein was observed in malignant schwannomas and in some neurofibroma cells. All cases were strongly positive for S-100 β-protein but were negative for GFAP and gal C. Our results suggest that these Schwann cell-related markers may be useful in identifying peripheral nerve sheath neoplasms as well as their malignant transformation.

Original languageEnglish (US)
Pages (from-to)812-819
Number of pages8
JournalMuscle and Nerve
Volume14
Issue number9
StatePublished - 1991
Externally publishedYes

Keywords

  • malignant schwannoma
  • neurofibroma
  • NGF receptor
  • S-100 protein
  • schwannoma

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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    Yasuda, T., Sobue, G., Ito, T., Doyu, M., Sugiura, I., Hashizume, Y., & Kato, K. (1991). Human peripheral nerve sheath neoplasm: Expression of Schwann cell-related markers and their relation to malignant transformation. Muscle and Nerve, 14(9), 812-819.