Human peripheral nerve sheath neoplasm

Expression of Schwann cell-related markers and their relation to malignant transformation

T. Yasuda, G. Sobue, Takayuki Ito, M. Doyu, I. Sugiura, Y. Hashizume, K. Kato

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

We immunohistochemically examined the expression of Schwann cell-related markers, nerve growth factor (NGF) receptor, S-100 α- and β-proteins, glial fibrillary acidic protein (GFAP), and galactocerebroside (gal C) in 5 malignant schwannomas, 21 benign peripheral nerve sheath tumors, and 4 apparently normal sural nerves. NGF receptor was expressed in the malignant schwannomas and benign peripheral nerve sheath tumors, but not in the endoneurium of apparently normal peripheral nerves. S-100 α-protein was observed in malignant schwannomas and in some neurofibroma cells. All cases were strongly positive for S-100 β-protein but were negative for GFAP and gal C. Our results suggest that these Schwann cell-related markers may be useful in identifying peripheral nerve sheath neoplasms as well as their malignant transformation.

Original languageEnglish (US)
Pages (from-to)812-819
Number of pages8
JournalMuscle and Nerve
Volume14
Issue number9
StatePublished - 1991
Externally publishedYes

Fingerprint

Peripheral Nervous System Neoplasms
Nerve Sheath Neoplasms
S100 Proteins
Schwann Cells
Neurilemmoma
Nerve Growth Factor Receptor
Glial Fibrillary Acidic Protein
Peripheral Nerves
Neurofibroma
Sural Nerve
Protein C

Keywords

  • malignant schwannoma
  • neurofibroma
  • NGF receptor
  • S-100 protein
  • schwannoma

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Yasuda, T., Sobue, G., Ito, T., Doyu, M., Sugiura, I., Hashizume, Y., & Kato, K. (1991). Human peripheral nerve sheath neoplasm: Expression of Schwann cell-related markers and their relation to malignant transformation. Muscle and Nerve, 14(9), 812-819.

Human peripheral nerve sheath neoplasm : Expression of Schwann cell-related markers and their relation to malignant transformation. / Yasuda, T.; Sobue, G.; Ito, Takayuki; Doyu, M.; Sugiura, I.; Hashizume, Y.; Kato, K.

In: Muscle and Nerve, Vol. 14, No. 9, 1991, p. 812-819.

Research output: Contribution to journalArticle

Yasuda, T, Sobue, G, Ito, T, Doyu, M, Sugiura, I, Hashizume, Y & Kato, K 1991, 'Human peripheral nerve sheath neoplasm: Expression of Schwann cell-related markers and their relation to malignant transformation', Muscle and Nerve, vol. 14, no. 9, pp. 812-819.
Yasuda, T. ; Sobue, G. ; Ito, Takayuki ; Doyu, M. ; Sugiura, I. ; Hashizume, Y. ; Kato, K. / Human peripheral nerve sheath neoplasm : Expression of Schwann cell-related markers and their relation to malignant transformation. In: Muscle and Nerve. 1991 ; Vol. 14, No. 9. pp. 812-819.
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