Abstract
We measured the plasma levels of atrial natriuretic factor (ANF) during orthotopic liver transplantation (OLT) in eight adult patients with cirrhosis and ascites. The aim of this study was to determine whether significant differences in ANF concentration may be detected during the individual phases of OLT and to correlate these changes with hemodynamics. In each patient a hemodynamic assessment was achieved using a Swan-Ganz fiber optic catheter for continuous monitoring of cardiac output (CO), systemic vascular resistance index (SVRI), right filling pressure as assessed by central venous pressure (CVP), and left filling pressure by means of pulmonary arterial wedge pressure (PAWP). During reperfusion a clear-cut increase in ANF values was observed (P<0.05). Concurrently, an increase in CVP (P<0.05) and a decrease in SVRI were observed without any significant increase in diuresis. These data suggest that ANF might play a role in the development of the reperfusion syndrome.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 51-54 |
| Number of pages | 4 |
| Journal | Transplant International |
| Volume | 8 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1995 |
| Externally published | Yes |
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Keywords
- Atrial natriuretic factor, liver transplantation
- Liver transplantation, atrial natriuretic factor
ASJC Scopus subject areas
- Transplantation
Cite this
Human natriuretic factor in cirrhotic patients undergoing orthotopic liver transplantation. / Piccinni, Pasquale; Rossaro, Lorenzo; Graziotto, Agnese; Tripepi, Antonio; Meneghetti, Leonardo; Inturri, Paolo; Burra, Patrizia; Rao, Thrinadha Polamarasetti; Plebani, Mario; Faggian, Diego.
In: Transplant International, Vol. 8, No. 1, 01.1995, p. 51-54.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Human natriuretic factor in cirrhotic patients undergoing orthotopic liver transplantation
AU - Piccinni, Pasquale
AU - Rossaro, Lorenzo
AU - Graziotto, Agnese
AU - Tripepi, Antonio
AU - Meneghetti, Leonardo
AU - Inturri, Paolo
AU - Burra, Patrizia
AU - Rao, Thrinadha Polamarasetti
AU - Plebani, Mario
AU - Faggian, Diego
PY - 1995/1
Y1 - 1995/1
N2 - We measured the plasma levels of atrial natriuretic factor (ANF) during orthotopic liver transplantation (OLT) in eight adult patients with cirrhosis and ascites. The aim of this study was to determine whether significant differences in ANF concentration may be detected during the individual phases of OLT and to correlate these changes with hemodynamics. In each patient a hemodynamic assessment was achieved using a Swan-Ganz fiber optic catheter for continuous monitoring of cardiac output (CO), systemic vascular resistance index (SVRI), right filling pressure as assessed by central venous pressure (CVP), and left filling pressure by means of pulmonary arterial wedge pressure (PAWP). During reperfusion a clear-cut increase in ANF values was observed (P<0.05). Concurrently, an increase in CVP (P<0.05) and a decrease in SVRI were observed without any significant increase in diuresis. These data suggest that ANF might play a role in the development of the reperfusion syndrome.
AB - We measured the plasma levels of atrial natriuretic factor (ANF) during orthotopic liver transplantation (OLT) in eight adult patients with cirrhosis and ascites. The aim of this study was to determine whether significant differences in ANF concentration may be detected during the individual phases of OLT and to correlate these changes with hemodynamics. In each patient a hemodynamic assessment was achieved using a Swan-Ganz fiber optic catheter for continuous monitoring of cardiac output (CO), systemic vascular resistance index (SVRI), right filling pressure as assessed by central venous pressure (CVP), and left filling pressure by means of pulmonary arterial wedge pressure (PAWP). During reperfusion a clear-cut increase in ANF values was observed (P<0.05). Concurrently, an increase in CVP (P<0.05) and a decrease in SVRI were observed without any significant increase in diuresis. These data suggest that ANF might play a role in the development of the reperfusion syndrome.
KW - Atrial natriuretic factor, liver transplantation
KW - Liver transplantation, atrial natriuretic factor
UR - http://www.scopus.com/inward/record.url?scp=0028954373&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028954373&partnerID=8YFLogxK
U2 - 10.1007/BF00366711
DO - 10.1007/BF00366711
M3 - Article
C2 - 7888052
AN - SCOPUS:0028954373
VL - 8
SP - 51
EP - 54
JO - Transplant International
JF - Transplant International
SN - 0934-0874
IS - 1
ER -