Human milk glycobiome and its impact on the infant gastrointestinal microbiota

Angela M. Zivkovic, J. Bruce German, Carlito B Lebrilla, David A. Mills

Research output: Contribution to journalArticle

336 Citations (Scopus)

Abstract

Human milk contains an unexpected abundance and diversity of complex oligosaccharides apparently indigestible by the developing infant and instead targeted to its cognate gastrointestinal microbiota. Recent advances in mass spectrometry-based tools have provided a view of the oligosaccharide structures produced in milk across stages of lactation and among human mothers. One postulated function for these oligosaccharides is to enrich a specific "healthy" microbiota containing bifidobacteria, a genus commonly observed in the feces of breast-fed infants. Isolated culture studies indeed showselective growth of infant-borne bifidobacteria on milk oligosaccharides or core components therein. Parallel glycoprofiling documented that numerous Bifidobacteriumlongum subsp. infantis strains preferentially consume small mass oligosaccharides that are abundant early in the lactation cycle. Genome sequencing of numerous B. longum subsp. infantis strains shows a bias toward genes required to use mammalian-derived carbohydrates by comparison with adult-borne bifidobacteria. This intriguing strategy of mammalian lactation to selectively nourish genetically compatible bacteria in infants with a complex array of free oligosaccharides serves as a model of how to influence the human supraorganismal system, which includes the gastrointestinal microbiota.

Original languageEnglish (US)
Pages (from-to)4653-4658
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume108
Issue numberSUPPL. 1
DOIs
StatePublished - Mar 15 2011

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Human Milk
Oligosaccharides
Bifidobacterium
Lactation
Milk
Microbiota
Feces
Gastrointestinal Microbiome
Mass Spectrometry
Breast
Mothers
Carbohydrates
Genome
Bacteria
Growth
Genes

Keywords

  • Bifidobacterium
  • Diet
  • Glycoprofiling
  • Human milk oligosaccharides
  • Infant microbiota

ASJC Scopus subject areas

  • General

Cite this

Human milk glycobiome and its impact on the infant gastrointestinal microbiota. / Zivkovic, Angela M.; German, J. Bruce; Lebrilla, Carlito B; Mills, David A.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, No. SUPPL. 1, 15.03.2011, p. 4653-4658.

Research output: Contribution to journalArticle

Zivkovic, Angela M. ; German, J. Bruce ; Lebrilla, Carlito B ; Mills, David A. / Human milk glycobiome and its impact on the infant gastrointestinal microbiota. In: Proceedings of the National Academy of Sciences of the United States of America. 2011 ; Vol. 108, No. SUPPL. 1. pp. 4653-4658.
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