Human immunodeficiency virus type 1 expression in the central nervous system correlates directly with extent of disease

Barbara Weiser, Nancy Peress, Debra L A Neve, David J. Eilbott, Roberta Seidman, Harold Burger

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

To investigate human immunodeficiency virus type 1 (HIV-1) pathogenesis in infected individuals and examine the correlation of HIV-1 expression with extent of clinical and pathologic disease, we studied spinal cords from acquired immunodeficiency syndrome patients with a wide range of spinal cord pathology. By performing in situ hybridization with HIV-1-specific riboprobes, we detected HIV-1 RNA in all 10 cords from acquired immunodeficiency syndrome patients with a common, characteristic pathologic entity called vacuolar myelopathy but not in 10 control cords from HIV-1-infected and uninfected patients. In the cords from individuals with vacuolar myelopathy, the level of HIV-1 RNA expression correlated directly with extent of spinal cord pathology and clinical findings. These data support a role for HIV-1 in the pathogenesis of tissue damage and related clinical disease in infected individuals.

Original languageEnglish (US)
Pages (from-to)3997-4001
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume87
Issue number10
StatePublished - 1990
Externally publishedYes

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Keywords

  • Acquired immunodeficiency syndrome
  • Immunohistochemistry
  • In situ hybridization
  • Vacuolar myelopathy

ASJC Scopus subject areas

  • Genetics
  • General

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