Human herpesvirus-8 (HHV-8) associated with small non-cleaved cell lymphoma in a child with AIDS

Charles T. Leach, Christopher Frantz, David R. Head, Shou Jiang Gao, Kenneth L. McClain, Maimon Cohen, Andrew B. Campbell, Bradley H Pollock, Sharon B. Murphy, Hal B. Jenson

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

The association of human herpesvirus-8 (HHV-8) with a small non-cleaved cell lymphoma is described in a child with the acquired immunodeficiency syndrome (AIDS) who developed a malignant pleural effusion and radiologic evidence of multiple solid tumors. HHV-8 DNA and Epstein-Barr virus DNA were identified in pleural fluid cells by polymerase chain reaction (PCR) amplification. The serum antibody titer against lytic HHV-8 proteins was 1:640; antibodies to latent HHV-8 proteins were not detected. Cytogenetic analysis of malignant cells revealed three abnormal karyotypes sharing the common finding of a t(8;14) translocation. Rearrangement of c-myc was demonstrated by PCR analysis. Oligoclonal JH immunoglobulin bands were found. Insufficient pleural fluid cells were available to permit localization of HHV-8 to malignant cells by in situ hybridization. This malignancy contrasts with HHV-8-associated lymphomas reported in adult patients with AIDS with respect to cell morphology, c-myc translocation, and oligoclonal immunoglobulin gene rearrangement. HHV-8 is associated with a wider spectrum of malignancies than recognized previously.

Original languageEnglish (US)
Pages (from-to)215-221
Number of pages7
JournalAmerican Journal of Hematology
Volume60
Issue number3
DOIs
StatePublished - 1999
Externally publishedYes

Keywords

  • AIDS
  • Human herpesvirus 8
  • Small non-cleaved cell lymphoma

ASJC Scopus subject areas

  • Hematology

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    Leach, C. T., Frantz, C., Head, D. R., Gao, S. J., McClain, K. L., Cohen, M., Campbell, A. B., Pollock, B. H., Murphy, S. B., & Jenson, H. B. (1999). Human herpesvirus-8 (HHV-8) associated with small non-cleaved cell lymphoma in a child with AIDS. American Journal of Hematology, 60(3), 215-221. https://doi.org/10.1002/(SICI)1096-8652(199903)60:3<215::AID-AJH8>3.0.CO;2-F